A flexible pouch and valve assembly is provided for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The flexible pouch and valve assembly are receivable within a relatively rigid housing, and are adapted to cooperate with a pump for pumping discrete portions of substance from the pouch and through the one-way valve to dispense the substance therefrom. The assembly comprises a flexible pouch defining therein a variable-volume storage chamber sealed with respect to the ambient atmosphere for aseptically storing therein multiple portions of the substance. A one-way valve of the assembly includes a valve body defining an axially-extending valve seat and at least one flow aperture extending through the valve body and/or the valve seat.

A child-resistant cartridge adapted to be used with an automatic brewing machine. The cartridge has a base and a lidding. The base can contain a pharmaceutical active. The lidding can be a multilayer laminate with an outer layer and an inner layer. The cartridge can be made out of tear resistant materials that are sufficient to prevent 70% of children from accessing the contents of three or more cartridges during a Child-Resistant Screening Test.

The invention relates to a method for loading and storing a vaccine composition, containing the antigen adsorbed on the aluminum adjuvant which (a) comprises (i) loading the composition into a container; and (ii) closing the container with a device in particular acting as a stopper, the surface of the device getting into contact with the composition being coated with a fluoropolymer such as Teflon? and/or (b) loading the composition into a container wherein the inner surface of which is coated with polymerized silicone. The use of fluoropolymer or polymerized silicone optimizes the adsorbed antigen stability upon storage. In a particular embodiment, the antigen is the hepatitis B surface antigen and the aluminum adjuvant is aluminum oxy hydroxide.

A sealing structure may include a lid including a first lid face, a second lid face opposite to the first lid face, and a fragile area between the first lid face and the second lid face, a cover including a first cover face facing the second lid face and covering the fragile area and a second cover face opposite to the first cover face, wherein a first distance between the second lid face and the first cover face is substantially equal to or less than a second distance between the first cover face and the second cover face, and a connector configured to connect the lid and the cover.

A valve includes a valve housing and an elastic valve member accommodated in the valve housing. The valve member is configured to close the valve when the valve is in a closed operating state. The valve member has a valve opening configured to be closed when the valve is in the closed operating state and to provide fluid passage through the valve when the valve is in an open operating state. The valve member is overmolded into the valve housing. The valve is beneficially used as a valve element of a port of a cap for a fluid container, in particular for a container for a medical fluid.

A fuel tank cap includes: a cap body which opens and closes a fuel supply port of a fuel tank; a ring member which is disposed around the fuel supply port and is shaped so as to surround the cap body; and a hinge member which is coupled to the ring member to support the cap body in a turnable manner between a closed position and an open position. A first peripheral part of the ring member, which is opposed to an outer periphery of the cap body, has a larger dimension in a circumferential direction than a dimension of a second peripheral part of the hinge member, which is opposed to the outer periphery of the cap body. The ring member and the hinge member are made of mutually different materials.

A versatile container a versatile pipe section comprising a sleeve and a tube inserted into the sleeve, the tube being held in place using a first capping element at a first end, at least one mounting element in a middle portion and a second capping element at a second end. The first and second capping elements are provided with an opening of a diameter corresponding to the diameter of the tube for allowing liquid or gas to flow through the tube. Also, a versatile container comprising a sleeve, at least one liquid or gas holding compartment adapted to be positioned within the sleeve, the at least one compartment being held in place using at least one mounting element. The sleeves are adapted to hold the contents of the tube or the at least one compartment in case of a leak.

A versatile container a versatile pipe section comprising a sleeve and a tube inserted into the sleeve, the tube being held in place using a first capping element at a first end, at least one mounting element in a middle portion and a second capping element at a second end. The first and second capping elements are provided with an opening of a diameter corresponding to the diameter of the tube for allowing liquid or gas to flow through the tube. Also, a versatile container comprising a sleeve, at least one liquid or gas holding compartment adapted to be positioned within the sleeve, the at least one compartment being held in place using at least one mounting element. The sleeves are adapted to hold the contents of the tube or the at least one compartment in case of a leak.

A can cover having an inner cover comprising a circular groove in which an upper sealing portion of said can is inserted. An inner O-ring is tightly attached to said upper sealing portion of said can. Said inner O-ring is inserted into said circular groove of said inner cover. Also included is an outer coupling ring having a plurality of coupling protrusions inserted into a plurality of coupling grooves formed in an outer circumferential portion of said inner cover. A clearance is formed between said coupling grooves such that when said outer coupling ring is separated from said inner cover, said clearance spreads and separates said inner cover from said upper sealing portion of said can.

Packaging which can accommodate medical articles such as a series of orthopedic implants e.g. femoral stem components for prosthetic hip joints which have a dimension which varies minimally across the series but which vary considerably in overall size. The packaging is designed to minimize the travel of any member of the series packaged therein such that all the packaged components in the series can pass the standard handling and shipping tests typically used by the manufacturers of medical articles such as implants and preferably comprises two thermoformed tray components which each carry three types of cavities which are interconnected and designed to be assembled with their cavities facing each other to contain the lower stem, body and angled shaft of the stem component, respectively, with the cavities for the lower stem and the body cooperating to capture a minimally varying dimension of the series.