The invention relates to a plastic container having a container wall delimiting an interior of the container, and an outlet on the container wall for pouring out a product contained in the plastic container. A recess that projects into the interior of the container and is provided for accepting a functional element is formed on the container wall, with the recess being accessible through an insertion hole.

A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5″ position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

A container including a finish defining an opening at a first end of the container that provides access to an internal volume defined by the container. A base portion of the container includes a diaphragm that is concave relative to an exterior of the container. The diaphragm extends from a standing surface of the container to a center push-up portion of the base portion. The standing surface is at a second end of the container opposite to the first end. The diaphragm is configured to move from an as-blown first configuration to a second configuration in which the diaphragm is closer to the first end as compared to the first configuration in order to reduce residual vacuum within the container. The diaphragm is generally hemispherical in cross-section when in the second configuration.

A security packaging provides a structure for providing evidence of package tampering. The packaging includes a first panel having an opening, and a foil label at least partially overlaying the opening and at least partially adhered to an insert member. Upon separation of the insert member from the packaging, at least a portion of the foil label is separated from the foil label thereby leaving a visual void in the opening indicating that the separation has occurred.

A security packaging provides a structure for providing evidence of package tampering. The packaging includes a first panel having an opening, and a foil label at least partially overlaying the opening and at least partially adhered to an insert member. Upon separation of the insert member from the packaging, at least a portion of the foil label is separated from the foil label thereby leaving a visual void in the opening indicating that the separation has occurred.

The present disclosure describes a hot-fill container for use with a hot-filling process. The container includes vacuum absorption sections that resist partial collapse and uncontrolled deformation of the container's walls during the hot-filling process. The vacuum absorption sections are asymmetrically-formed and include respective edge portions and panel portions configured to deform and pivot about a linear part of the edge portions when a vacuum is created inside the container. The edge portions have a curvilinear part that is adapted to comfortably receive and engage a user's fingers during use of the container, making the container more user friendly. The vacuum absorption sections are arranged about the container's central longitudinal axis such that their respective panel portions substantially form the sides of a polygon when viewed in top plan view. The polygon appears to be inscribed within an otherwise circular container periphery.

Systems and methods here may be used to sense razor handle usage, and/or product content in a container, send information to a local wireless device which may in turn, inform a back end system. In some embodiments, the systems and methods may then utilize the information about the container and send a message regarding inventory status, place an order for a re-fill, and/or aggregate usage data of the container or handle.

A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

A tag for a bottle having a neck, wherein the tag comprises a band for engaging the neck of the bottle and a label portion extending from the band. The band frictionally engages the whole circumference of the neck of the bottle in order to maintain the placement of the tag on the exterior surface of the neck of the bottle. The label portion of the tag extends outwardly from the band at an angle with respect to the vertical axis of the bottle neck.