A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5 position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

A new class of pseudo-trisaccharide aminoglycosides having an alkyl group at the 5 position, exhibiting efficient stop codon mutation readthrough activity, low cytotoxicity and high selectivity towards eukaryotic translation systems are provided. Also provided are pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders, as well as processes of preparing these aminoglycosides. The disclosed aminoglycosides can be represented by the general formula I: ##STR00001##
or a pharmaceutically acceptable salt thereof, wherein R.sub.1 is selected from the group consisting of alkyl, cycloalkyl and aryl; and all other variables and features are as described in the specification.

A package, for example, a freezable microwavable package containing a food product, has a sealing film that includes a vent system that is scored into the package.

A product with packaging includes an envelope having a cavity. An NFC chip may be embedded in the packaging. The NFC chip may be passive, and may connect to the electronic device of the specific user, and once connected may initiate or carry out an authentication process or activation process.

A product with packaging includes an envelope having a cavity. An NFC chip may be embedded in the packaging. The NFC chip may be passive, and may connect to the electronic device of the specific user, and once connected may initiate or carry out an authentication process or activation process.

A plastic, hot-fillable container is provided. The container comprises a blow molded body including a neck and a base having a center portion and a plurality of spaced apart radial segments. At least a portion of each segment is tapered from an outer side to an inner side thereof. Container systems and methods of manufacturing containers are disclosed.

A plastic container comprises an upper portion including a finish defining an opening into the container, a lower portion including a base defining a standing surface, a sidewall extending between the upper portion and the lower portion, the sidewall defining a longitudinal axis, and at least one substantially transversely-oriented pressure panel located in the lower portion. The pressure panel is movable between an outwardly-inclined position and an inwardly-inclined position to compensate for a change of pressure inside the container. The standing surface defines a standing plane, and the entire pressure panel is located between the standing plane and the upper portion of the container when the pressure panel is in the outwardly-inclined position.

A synthetic resin container that effectively absorbs reduced pressure generated inside the container due to hot filling to maintain the appearance and shape. A synthetic resin container includes a mouth as a dispensing spout for a content medium, a trunk, extending contiguous to the mouth via a shoulder, and a bottom, closing a lower end of the trunk. The trunk is provided with reduced pressure absorbing panels, which are formed as ribs extending in the vertical direction while twisting in the circumferential direction about a central axis of the trunk and which are arranged side by side in the circumferential direction of the trunk. Twist angle of a lower end with respect to an upper end of each reduced pressure absorbing panel about the central axis is 50 degrees or more.

A container having an inverted active cage generally includes an enclosed base portion, a body portion extending upwardly from the base portion, and a top portion with a finish extending upwardly from the body portion. The body portion further includes a central longitudinal axis, a periphery, a plurality of rigidified and non-active surfaces, and a network of pillars or channels. Unlike the prior art, each of the plurality of non-active surfaces is outwardly displaced with respect to the longitudinal axis, while each of the network of pillars or channels is inwardly displaced with respect to the longitudinal axis. The plurality of rigidified or non-active surfaces, together with the network of rigidified channels or pillars, are spaced about the periphery of the container in order to accommodate vacuum-induced volumetric shrinkage of the container resulting from a hot-filling, capping and cooling thereof.

A container includes a base, a neck portion, and a body positioned between the base and the neck portion. The base includes a plurality of feet with a plurality of recesses positioned between the plurality of feet. The body includes a plurality of ribs, a plurality of channels, and a plurality of support columns. The plurality of ribs extend around a periphery of the body and along at least a portion of a height of the body. The plurality of channels extend around the periphery and are positioned between the plurality of ribs. The plurality of support columns are spaced about the periphery and extend along at least a portion of the height of the body. Each of the plurality of support columns includes a plurality of protrusions that are vertically aligned. Each of the plurality of protrusions is disposed within a respective one of the plurality of channels.