Because antimicrobial preservatives used in virtually all cosmetics exhibit degrees of adverse human toxicity that have become of increasing concern, a three element system is disclosed that eliminates the need for cosmetic preservatives and their degradation fragments that may exhibit toxicity. Element 1 comprises a cosmetic formulation not containing any preservative components. Element 2 is an individual unit dose of an Element 1 cosmetic formulation in a microbially-impenetrable disposable container. Element 3 comprises the sterilization of the sealed unit dose disposable container, employing heat or, preferably, employing ionizing radiation.

A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.

A liquid sample bulk mailing packaging device includes a paperboard envelope blank assembled to form a hermetically sealed leakproof containment pocket such that a moisture resistant coating on .Iadd.at least .Iaddend.one of the paperboard surfaces will prevent leakage in the event an enclosed liquid containing packette fails during mail processing, while .Iadd.if uncoated .Iaddend.the other paperboard surface will absorb the moisture from the packette. The device meets the US Postal Service requirements for machinable and automation letters.

Because antimicrobial preservatives used in virtually all cosmetics exhibit degrees of adverse human toxicity that have become of increasing concern, a three element system is disclosed that eliminates the need for cosmetic preservatives and their degradation fragments that may exhibit toxicity. Element 1 comprises a cosmetic formulation not containing any preservative components. Element 2 is an individual unit dose of an Element 1 cosmetic formulation in a microbially-impenetrable disposable container. Element 3 comprises the sterilization of the sealed unit dose disposable container, employing heat or, preferably, employing ionizing radiation.

A sealed single-dose break-open package including a first sheet of semirigid plastic material; a second sheet of flexible plastic material superimposed on and sealed to the first sheet to define a sealed pocket containing a dose of a product; wherein the first sheet of semirigid plastic material includes at least one substantially straight first incision positioned at a first edge of the first sheet, and at least one shaped incision positioned in a central portion of the first sheet, laterally and at a distance from the straight first incision.

The present invention relates to a child resistant closure for a bottle or container. More specifically, the present invention relates to improved two-cap structure assemblies.

A fluid dispensing container is provided. The container includes a container body formed from a first flexible material defining an interior cavity. The container includes a membrane formed from a second flexible material and a seal coupling the membrane to the inner surface of the container body. The membrane divides the interior cavity into a contents chamber and a dispensing chamber, and the membrane and the seal are configured to be fluid tight to maintain fluid within the contents chamber prior to rupture of the membrane. The rupture stress of the second flexible material is less than the rupture stress of the first flexible material such that, as fluid pressure within the contents chamber increases, the membrane is configured to rupture without the container body rupturing.

A break-open single-dose package includes at least one support panel movable to fold the break-open single-dose package, a sealable pocket for storing a spreadable consumable, an applicator, and one or more grips adjacent the at least one support panel. The sealable pocket is positioned adjacent the at least one support panel and includes a frangible region adapted to form an opening through which the spreadable consumable can exit the pocket in response to folding of the break-open single-dose package. The applicator is positioned adjacent the frangible region of the pocket for permitting a user to spread any spreadable consumable that exits the pocket on a surface using the applicator without requiring the user's hand(s) to contact the spreadable consumable. The one or more grips are positioned and adapted to facilitate user control of the break-open single-dose package. Other example single-dose packages are also disclosed.

A vial for fluid products, particularly pharmaceutical, cosmetic, and medical products has a containment body closed by a closing element removable along a predetermined breaking line, and an opening key slidingly fitted onto the closing element and prismatically rotationally engageable with the closing element to remove the closing element from the containment body. The opening key is prismatically engageable with the closing element by inserting prismatic protrusions of the closing element into special recesses of the opening key.

A sealed single-dose break-open package including a first sheet of semirigid plastic material; a second sheet of flexible plastic material superimposed on and sealed to the first sheet to define a sealed pocket containing a dose of a product; wherein the first sheet of semirigid plastic material includes at least one substantially straight first incision positioned at a first edge of the first sheet, and at least one shaped incision positioned in a central portion of the first sheet, laterally and at a distance from the straight first incision.