The present application is directed to composition comprising various maca extracts and the use of such compositions for treating certain diseases, disorders, and conditions.

The present invention describes compositions, and associated methods, comprising a cannabinoid operably linked with a biologically active agent for augmented cannabinoid agents.

[Problem] A preparation of forming bubbles of carbon dioxide gas which is put into a micro-bubble generator is realized, unlike a conventional tablet, as a tablet which can retain an ability to neutralize and remove completely chlorine contained in tap water from start of dissolution of the tablet inside the micro-bubble generator to the completion of dissolution thereof, thereby providing a method for producing micro-bubbles of carbon dioxide gas by using the tablet and a device thereof. [Solution] There is provided a method for producing carbon dioxide gas/micro-bubbles mixed water in which a carbonated bathing agent is a tablet which is 7 mm or more both in tablet diameter and tablet thickness, 15 kg or more in tablet hardness, 10 wt % or less in tablet friability and from 5.5 to 9.0 in pH immediately after dissolution of the tablet in hot water and the carbonated bathing agent contains at least one of the following body rendering agents and contains at least one of the following chlorine neutralizing compounds.

[Problem] A preparation of forming bubbles of carbon dioxide gas which is put into a micro-bubble generator is realized, unlike a conventional tablet, as a tablet which can retain an ability to neutralize and remove completely chlorine contained in tap water from start of dissolution of the tablet inside the micro-bubble generator to the completion of dissolution thereof, thereby providing a method for producing micro-bubbles of carbon dioxide gas by using the tablet and a device thereof. [Solution] There is provided a method for producing carbon dioxide gas/micro-bubbles mixed water in which a carbonated bathing agent is a tablet which is 7 mm or more both in tablet diameter and tablet thickness, 15 kg or more in tablet hardness, 10 wt % or less in tablet friability and from 5.5 to 9.0 in pH immediately after dissolution of the tablet in hot water and the carbonated bathing agent contains at least one of the following body rendering agents and contains at least one of the following chlorine neutralizing compounds.

The present invention relates to a phytocomplex or natural concentrate, rich in polyphenol compounds, such as hydroxytyrosol and Oleuropein-aglycone di-aldehyde (3,4-DHPA-EDA), derived from the pressing waters of oil olives and/or from pomace from the olive grinding process, for use in the prevention and/or treatment of damage to the cardiovascular system, preferably in subjects affected by/suffering from hypertension, cardiac decompensation, arrhythmia, heart attacks or those subjected to chemotherapy. The present invention further relates to a composition comprising said concentrate and to the concentrate and/or composition formulated for oral use for example as a beverage, pills or the like, or as a support for topical applications, and the use thereof in the prevention and/or treatment of damage to the cardiovascular system, preferably in subjects affected by hypertension, cardiac decompensation, arrhythmia, heart attacks or those subjected to chemotherapy.

A beverage product comprising a beverage in a sealed container is provided. The beverage comprises, in water, a combination of buffering components selected from (a) citric acid and trisodium citrate, (b) tartaric acid and disodium tartrate, or (c) malic acid and disodium malate, and glucose and sodium chloride, wherein the beverage has a pH of lower than 4.0. A method and an apparatus suited for producing such a beverage product are also provided.

A beverage product comprising a beverage in a sealed container is provided. The beverage comprises, in water, a combination of buffering components selected from (a) citric acid and trisodium citrate, (b) tartaric acid and disodium tartrate, or (c) malic acid and disodium malate, and glucose and sodium chloride, wherein the beverage has a pH of lower than 4.0. A method and an apparatus suited for producing such a beverage product are also provided.

The present invention relates to a pharmaceutical composition for preventing or treating ovotoxicity, and more specifically, to a pharmaceutical composition for preventing or treating ovotoxicity, containing an Evodia rutaecarpa Bentham extract. According to the present invention, the Evodia rutaecarpa Bentham extract concentration-dependently increases DPPH free radical scavenging activity so as to have excellent antioxidant activity, inhibits apoptosis of ovarian cells, and activates a PI3K/Akt signaling pathway so as to have a significant protective effect against ovotoxicity to be caused by 4-vinylcyclohexene diepoxide (VCD), thereby being usable as a medicine and a health functional food, which are useful for alleviating, preventing, inhibiting or treating ovotoxicity, premature ovarian failure and the like. Therefore, subfertility treatment or prevention, premature ovarian failure, a menopausal disorder in the premenopausal period, and the like can be considered application examples related thereto.

The present invention relates to a pharmaceutical composition for preventing or treating ovotoxicity, and more specifically, to a pharmaceutical composition for preventing or treating ovotoxicity, containing an Evodia rutaecarpa Bentham extract. According to the present invention, the Evodia rutaecarpa Bentham extract concentration-dependently increases DPPH free radical scavenging activity so as to have excellent antioxidant activity, inhibits apoptosis of ovarian cells, and activates a PI3K/Akt signaling pathway so as to have a significant protective effect against ovotoxicity to be caused by 4-vinylcyclohexene diepoxide (VCD), thereby being usable as a medicine and a health functional food, which are useful for alleviating, preventing, inhibiting or treating ovotoxicity, premature ovarian failure and the like. Therefore, subfertility treatment or prevention, premature ovarian failure, a menopausal disorder in the premenopausal period, and the like can be considered application examples related thereto.

Provided is a solubilization enhancer for pyrroloquinoline quinone or a salt thereof in an aqueous solvent, comprising resistant dextrin as an active ingredient.