A preferred conformal penetrating multi electrode array includes a plastic substrate that is flexible enough to conform to cortical tissue. A plurality of penetrating semiconductor micro electrodes extend away from a surface of the flexible substrate and are stiff enough to penetrate cortical tissue. Electrode lines are encapsulated at least partially within the flexible substrate and electrically connected to the plurality of penetrating semiconductor microelectrodes. The penetrating semiconductor electrodes preferably include pointed metal tips. A preferred method of fabrication permits forming stiff penetrating electrodes on a substrate that is very flexible, and providing electrical connection to electrode lines within the substrate.

Methods for introducing exogenous material into a cell are provided, which include exposing the cell to a transient decrease in pressure in the presence of the exogenous material. Also provided are devices for performing the method of the invention.

Methods for introducing exogenous material into a cell are provided, which include exposing the cell to a transient decrease in pressure in the presence of the exogenous material. Also provided are devices for performing the method of the invention.

Embodiments of a packaged electronic device and method of fabricating such a device are provided, where the packaged electronic device includes: a pressure sensor die having a diaphragm on a front side; an encapsulant material that encapsulates the pressure sensor die, wherein the front side of the pressure sensor die is exposed at a first major surface of the encapsulant material; an interconnect structure formed over the front side of the pressure sensor die and the first major surface of the encapsulant material, wherein an opening through the interconnect structure is generally aligned to the diaphragm; and a cap attached to an outer dielectric layer of the interconnect structure, the cap having a vent hole generally aligned with the opening through the interconnect structure.

A Micro-Electro-Mechanical-System (MEMS) device and a method for operating the device are disclosed. The device includes a substrate platform and an electrode plate having a plurality of serpentine arms, the electrode plate attached to the substrate platform via the plurality of serpentine arms, the electrode plate provided on a plane in a resting position. The device includes a sharp member disposed substantially perpendicularly on the electrode plate. In various implementations, the electrode plate and the substrate platform are co-planar. In various implementations, the electrode plate is configured to move in a direction perpendicular to the plane away from the resting position. The device also includes a counter-electrode. The method of operating the device includes supplying, via a power source, a direct current (DC) across the electrode and the counter-electrode to generate an electrostatic field across the electrode and the counter-electrode of the device.

A sample loading cartridge (1) for a microfluidic device comprises a cartridge body (10) with a sample reservoir (20) configured to house a volume of a liquid sample (3) and a sample port (30) in connection with the sample reservoir (20). The cartridge (1) also comprises an output channel (40) extending from the sample reservoir (20) and a feedback channel (50) connected to the sample reservoir (20) and to the sample port (30). The cartridge body (10) comprises a detection portion (60) aligned with the feedback channel (50) to enable detection of any sample (3) in the feedback channel (50). The flow resistance of the feedback channel (50) is lower than the flow resistance of the output channel (40) to cause liquid sample (3) received in the sample port (30) to enter the feedback channel (50) with substantially no liquid sample (3) entering the output channel (40).

An article with controllable wettability includes a substrate and a layer of a composite material supported on the substrate. The layer has an exposed surface and the composite material includes particles that have controllable polarization embedded fully or partially in a matrix. A controller is operable to selectively apply a controlled variable activation energy to the layer. The controllable polarization of the particles varies responsive to the controlled variable activation energy such that a wettability of the exposed surface also varies responsive to the controlled variable activation energy.

An article with controllable wettability includes a substrate and a layer of a composite material supported on the substrate. The layer has an exposed surface and the composite material includes particles that have controllable polarization embedded fully or partially in a matrix. A controller is operable to selectively apply a controlled variable activation energy to the layer. The controllable polarization of the particles varies responsive to the controlled variable activation energy such that a wettability of the exposed surface also varies responsive to the controlled variable activation energy.

A microfluidic apparatus has a microchannel that includes at least one vertically oriented segment with a top section having a relatively wide opening and a bottom section having a relatively narrow opening. The top section is larger in volume relative to the bottom sections, and the middle sections taper down in at least one dimension from the top section to the bottom section. One or tens or hundreds of vertically-oriented segments may be provided, and they are fluidly coupled to each other. Each segment acts as a pressure-volume-temperature (PVT) cell, and the microchannel apparatus may be used to determine a parameter of a fluid containing hydrocarbons such as the dew point of the fluid or the liquid drop-out as a function of pressure.

A microfluidic apparatus has a microchannel that includes at least one vertically oriented segment with a top section having a relatively wide opening and a bottom section having a relatively narrow opening. The top section is larger in volume relative to the bottom sections, and the middle sections taper down in at least one dimension from the top section to the bottom section. One or tens or hundreds of vertically-oriented segments may be provided, and they are fluidly coupled to each other. Each segment acts as a pressure-volume-temperature (PVT) cell, and the microchannel apparatus may be used to determine a parameter of a fluid containing hydrocarbons such as the dew point of the fluid or the liquid drop-out as a function of pressure.