Patent classifications
C01B39/00
Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease
The present invention relates to novel methods of using microporous zirconium silicate to reduce the risk of hyperkalemia and to lower aldosterone levels in the treatment of chronic kidney disease and/or chronic heart disease with therapies comprising diuretics. The invention provides a safe way to reduce the risk of hyperkalemia and to lower aldosterone. The invention also relates to treatment of other conditions that can occur either alone or in connection with hyperkalemia, chronic kidney disease, and/or chronic heart disease.
Microporous zirconium silicate and diuretics for the reduction of potassium and treatment of chronic kidney and/or chronic heart disease
The present invention relates to novel methods of using microporous zirconium silicate to reduce the risk of hyperkalemia and to lower aldosterone levels in the treatment of chronic kidney disease and/or chronic heart disease with therapies comprising diuretics. The invention provides a safe way to reduce the risk of hyperkalemia and to lower aldosterone. The invention also relates to treatment of other conditions that can occur either alone or in connection with hyperkalemia, chronic kidney disease, and/or chronic heart disease.
Microporous zirconium silicate for the treatment of hyperkalemia
The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
Microporous zirconium silicate for the treatment of hyperkalemia
The present invention relates to novel microporous zirconium silicate compositions that are formulated to remove toxins, e.g. potassium ions, from the gastrointestinal tract at an elevated rate without causing undesirable side effects. The preferred formulations are designed avoid increase in pH of urine in patients and/or avoid potential entry of particles into the bloodstream of the patient. Also disclosed is a method for preparing high purity crystals of ZS-9 exhibiting an enhanced level of potassium exchange capacity. These compositions are particularly useful in the therapeutic treatment of hyperkalemia.
Aromatic hydrogenation catalysts and uses thereof
- Paul Podsiadlo ,
- Quanchang Li ,
- David Charles Calabro ,
- Jean Willem Lodewijk Beeckman ,
- Lei ZHANG ,
- Kiara M. BENITEZ ,
- Matthew Scott Ide ,
- Stephen John McCarthy ,
- Mobae Afeworki ,
- Simon Christopher Weston ,
- Preeti KAMAKOTI ,
- Matu J. Shah ,
- Wenyih Frank Lai ,
- Meghan Kochersperger ,
- David A. Griffin ,
- Ivy D. Johnson
Hydrogenation catalysts for aromatic hydrogenation including an organosilica material support, which is a polymer comprising independent units of a monomer of Formula [Z.sup.1OZ.sup.2OSiCH.sub.2].sub.3 (I), wherein each Z.sup.1 and Z.sup.2 independently represent a hydrogen atom, a C.sub.1-C.sub.4 alkyl group or a bond to a silicon atom of another monomer; and at least one catalyst metal are provided herein. Methods of making the hydrogenation catalysts and processes of using, e.g., aromatic hydrogenation, the hydrogenation catalyst are also provided herein.
Aromatic hydrogenation catalysts and uses thereof
- Paul Podsiadlo ,
- Quanchang Li ,
- David Charles Calabro ,
- Jean Willem Lodewijk Beeckman ,
- Lei ZHANG ,
- Kiara M. BENITEZ ,
- Matthew Scott Ide ,
- Stephen John McCarthy ,
- Mobae Afeworki ,
- Simon Christopher Weston ,
- Preeti KAMAKOTI ,
- Matu J. Shah ,
- Wenyih Frank Lai ,
- Meghan Kochersperger ,
- David A. Griffin ,
- Ivy D. Johnson
Hydrogenation catalysts for aromatic hydrogenation including an organosilica material support, which is a polymer comprising independent units of a monomer of Formula [Z.sup.1OZ.sup.2OSiCH.sub.2].sub.3 (I), wherein each Z.sup.1 and Z.sup.2 independently represent a hydrogen atom, a C.sub.1-C.sub.4 alkyl group or a bond to a silicon atom of another monomer; and at least one catalyst metal are provided herein. Methods of making the hydrogenation catalysts and processes of using, e.g., aromatic hydrogenation, the hydrogenation catalyst are also provided herein.
Porous Aluminum Pyrazoledicarboxylate Frameworks
A porous aluminum-based metal-organic framework (MOF) comprises inorganic aluminum chains linked via carboxylate groups of 1H-pyrazole-3,5-dicarboxylate (HPDC) linkers, and of formula: [Al(OH)(C.sub.5H.sub.2O.sub.4N.sub.2)(H.sub.2O)].
HYBRID MEMBRANE COMPRISING ZEOLITIC IMIDAZOLATE FRAMEWORK NANOPARTICLES AND METHOD OF GAS SEPARATION USING THE SAME
The present invention relates to a hybrid membrane mixed with nanoparticles including a zeolitic imidazolate framework (ZIF), and a gas separation method using the same. A hybrid membrane according to the present invention comprises a polymer matrix, and nanoparticles which are dispersed in the polymer matrix and include the ZIF.
Zeolite having a one-dimensional channel system, 10-membered rings and 12-membered rings
A new crystalline aluminosilicate zeolite comprising a novel framework has been synthesized that has been designated UZM-55. This zeolite is represented by a three-dimensional framework of at least SiO.sub.2 tetrahedral units and an empirical composition in the as-synthesized and anhydrous basis expressed by an empirical formula of:
M.sub.m.sup.n+R.sub.rAl.sub.xE.sub.ySiO.sub.z
where M represents a metal or metals from zinc or Group 1 (IUPAC 1), Group 2 (IUPAC 2), Group 3 (IUPAC 3) or the lanthanide series of the periodic table, R is a structure directing agent or agents such as 1,6-bis(N-methylpiperidinium)hexane, and E is an element selected from the group consisting of gallium, iron, boron and mixtures thereof. Catalysts made from UZM-55 have utility in various hydrocarbon conversion reactions including methanol to hydrocarbons (MTH).
Zeolite having a one-dimensional channel system, 10-membered rings and 12-membered rings
A new crystalline aluminosilicate zeolite comprising a novel framework has been synthesized that has been designated UZM-55. This zeolite is represented by a three-dimensional framework of at least SiO.sub.2 tetrahedral units and an empirical composition in the as-synthesized and anhydrous basis expressed by an empirical formula of:
M.sub.m.sup.n+R.sub.rAl.sub.xE.sub.ySiO.sub.z
where M represents a metal or metals from zinc or Group 1 (IUPAC 1), Group 2 (IUPAC 2), Group 3 (IUPAC 3) or the lanthanide series of the periodic table, R is a structure directing agent or agents such as 1,6-bis(N-methylpiperidinium)hexane, and E is an element selected from the group consisting of gallium, iron, boron and mixtures thereof. Catalysts made from UZM-55 have utility in various hydrocarbon conversion reactions including methanol to hydrocarbons (MTH).