The invention relates to [bis(trihydrocarbylsilyl)aminosilyl]-functionalized styrene and a method for its preparation. The invention further relates to the use of the styrene derivative in the preparation of a copolymer thereof. The styrene derivative is preferably used as comonomer in the production of elastomeric copolymers. Alternatively, or additionally, it is used in the preparation of a polymerization initiator.

An organic magnesium phosphide expressed by Formula (1) below and an organic magnesium phosphide complex expressed by Formula (9) below are provided, and a manufacturing method of organic phosphorus compound is characterized in that the above compounds used as a reagent is reacted with an electrophile:

##STR00001##

wherein R.sup.1 and R.sup.2 are each independently an aliphatic group, heteroaliphatic group, alicyclic group, or heterocyclic group, and X is chlorine, bromine, or iodine,

##STR00002##

wherein R.sup.3 and R.sup.4 are each independently an aliphatic group, heteroaliphatic group, aromatic group, alicyclic group, or heterocyclic group, and X and Y are each independently chlorine, bromine, or iodine.

The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m.sup.2/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m.sup.2/g.

The present application relates to a process for the preparation of crystalline form A of palbociclib having specific surface area more than 2 m.sup.2/g comprising one-pot process for the preparation of compound of formula (IV). The present application further relates to the preparation of acid-addition salts of palbociclib and their use for the synthesis of crystalline form A of palbociclib having specific surface area more than 2 m.sup.2/g.

The invention relates to a continuous method for the production of Grignard adducts, in which the magnesium chips are activated mechanically in situ. Furthermore, the invention relates to a device for implementation of the method according to the invention.

The present invention relates to a series of analogs of natural product Pyripyropene A represented by general formula I and a preparation method and use thereof. More particularly, the present invention relates to analogs of the natural product Pyripyropene A, a preparation method and use thereof as the acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors for the treatment of cardiovascular diseases such as atherosclerosis and the like. ##STR00001##

The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced. ##STR00001##

The present invention relates to a method for preparing a citalopram diol represented by formula IV, comprising the following steps: in the existence of an auxiliary reagent of metal salt, allowing 5-cyanophthalide to sequentially subjected to Grignard addition reactions with p-fluorophenyl magnesium halide and N, N-dimethylaminopropyl magnesium halide in an organic solvent; and after the reactions are completed, performing hydrolysis and separation to obtain citalopram diol represented by formula IV. In the present invention, by adding an auxiliary reagent of metal salt, the activity and the selectivity of the Grignard reactions are remarkably improved, and the reaction yield is obviously enhanced. ##STR00001##

The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R.sup.1 is a C.sub.1C.sub.18alkyl group or C.sub.2-C.sub.18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R.sup.1 is a C.sub.1-C.sub.18alkyl group or C.sub.2-C.sub.18alkenyl group and R.sup.2 and R.sup.3 are independently of each other a C.sub.1-C.sub.18alkyl group or a C.sub.2-C.sub.18alkenyl group. ##STR00001##

The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R.sup.1 is a C.sub.1C.sub.18alkyl group or C.sub.2-C.sub.18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R.sup.1 is a C.sub.1-C.sub.18alkyl group or C.sub.2-C.sub.18alkenyl group and R.sup.2 and R.sup.3 are independently of each other a C.sub.1-C.sub.18alkyl group or a C.sub.2-C.sub.18alkenyl group. ##STR00001##