In a process for the synthesis of a nitrile by endothermic catalyzed reaction of ammonia with a hydrocarbon using heating obtained by passing an alternating current through a metallic coil, the endothermic reaction between ammonia and the hydrocarbon takes place in a reactor with direct inductive heating in the reaction zone. The heating is extremely fast, which makes the reaction practically instantaneous.

The present invention is directed to processes for catalyzing two or more chemical reactions with a multifunctional catalyst in a reaction vessel. The processes include steps for introducing one or more reagents to a reaction vessel containing a multifunctional catalyst; contacting the one or more reagents with a first portion of the multifunctional catalyst to produce an intermediate; contacting the intermediate with a second portion of the multifunctional catalyst to produce a product; and removing the product from the reaction vessel. In certain embodiments, the multifunctional catalyst may have a first portion with carbonylation functionality for catalyzing the production of a beta-lactone intermediate from an epoxide reagent and a carbon monoxide reagent. In certain embodiments, the multifunctional catalyst may have a second portion with a functionality suitable for polymerization, co-polymerization, and/or modification of a beta-lactone intermediate. In preferred embodiments, the first portion and second portion are bonded to a heterogenous support.

The present invention is directed to processes for catalyzing two or more chemical reactions with a multifunctional catalyst in a reaction vessel. The processes include steps for introducing one or more reagents to a reaction vessel containing a multifunctional catalyst; contacting the one or more reagents with a first portion of the multifunctional catalyst to produce an intermediate; contacting the intermediate with a second portion of the multifunctional catalyst to produce a product; and removing the product from the reaction vessel. In certain embodiments, the multifunctional catalyst may have a first portion with carbonylation functionality for catalyzing the production of a beta-lactone intermediate from an epoxide reagent and a carbon monoxide reagent. In certain embodiments, the multifunctional catalyst may have a second portion with a functionality suitable for polymerization, co-polymerization, and/or modification of a beta-lactone intermediate. In preferred embodiments, the first portion and second portion are bonded to a heterogenous support.

The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enriched in D-alanine or L-alanine to an alanine racemase at a temperature of at least 50? C. and alkaline conditions for a time sufficient to allow conversion of said solution into a racemic alanine solution, obtaining a racemic alanine solution, and chemically converting the racemic alanine into racemic MGDA. The invention further contemplates an alanine racemase which is capable of converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50? C. and under alkaline conditions as well as the use of said alanine racemase for converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50? C. and under alkaline conditions.

The present invention relates to the field of chemical manufacture. In particular, it relates to a method for manufacturing racemic methylglycinediacetic acid (MGDA) comprising the steps of contacting a solution comprising or being enriched in D-alanine or L-alanine to an alanine racemase at a temperature of at least 50? C. and alkaline conditions for a time sufficient to allow conversion of said solution into a racemic alanine solution, obtaining a racemic alanine solution, and chemically converting the racemic alanine into racemic MGDA. The invention further contemplates an alanine racemase which is capable of converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50? C. and under alkaline conditions as well as the use of said alanine racemase for converting a solution comprising or being enriched in D-alanine or L-alanine into racemic alanine solution at a temperature of at least 50? C. and under alkaline conditions.

A compound, having a structure represented by a formula (I), ##STR00001## and prepared by one-pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.

A compound, having a structure represented by a formula (I), ##STR00001## and prepared by one-pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.

The present invention provides high purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile, including the following step 1 and step 2: step 1: a step of subjecting 2-acetonaphthone to a Willgerodt reaction in the presence of an additive where necessary, and hydrolyzing the obtained amide compound to give 2-naphthylacetic acid; step 2: a step of reacting the 2-naphthylacetic acid obtained in step 1, a halogenating agent and sulfamide in the presence of a catalyst as necessary in an organic solvent to give 2-naphthylacetonitrile.

The present invention provides high purity 2-naphthylacetonitrile with fewer impurities that is useful as a starting material or intermediate for the synthesis of various pharmaceutical products, agricultural chemicals, and chemical products, and a production method thereof. A high purity 2-naphthylacetonitrile having an HPLC purity of 2-naphthylacetonitrile of not less than 95 area %, and containing naphthalene compounds represented by the formulas (a)-(j) at a content of a predetermined area % or below. A method for producing high purity 2-naphthylacetonitrile, including the following step 1 and step 2: step 1: a step of subjecting 2-acetonaphthone to a Willgerodt reaction in the presence of an additive where necessary, and hydrolyzing the obtained amide compound to give 2-naphthylacetic acid; step 2: a step of reacting the 2-naphthylacetic acid obtained in step 1, a halogenating agent and sulfamide in the presence of a catalyst as necessary in an organic solvent to give 2-naphthylacetonitrile.

Process for preparation of a mixture of methyl glycine diacetic acid (MGDA) or its respective mono-, di-, trialkali metal salt or its respective mono-, di- or tri-ammonium salt or mixtures thereof, and glutamic acid diacetic acid (GLDA) or its respective mono-, di-, tri-, or tetra-alkali metal or mono-, di-, tri- or tetra-ammonium salt or mixtures thereof, wherein said process com-prises the steps of: (a) dissolution in water of (a1) alanine in its L- or D-enantiomeric form or its respective monoalkali metal salt or mixtures thereof, and (a2) glutamic acid as L- or D-enantiomer or its respective mono-, or dialkali metal or mixtures thereof, wherein the molar ratio of alanine to glutamic acid is in the range of from 1:9 to 9:1, (b) converting the mixture obtained in step (a) with formaldehyde and hydrocyanic acid or alkali metal cyanide to the corresponding dinitriles, (c) saponification of the dinitriles resulting from step (b).