The present invention provides a process for the preparation of Teriflunomide (Formula-I). The present invention describes the synthesis of Teriflunomide without isolating the intermediate Leflunomide. Teriflunomide is prepared from 5-Methyl isoxazole-4-carboxylic acid by converting to its acid chloride and coupling with 4-trifluoromethyl aniline to obtain Leflunomide (which is not isolated) followed by ring opening reaction using aq. Sodium Hydroxide to form Teriflunomide. In other words, the process is telescoped from 5-methylisoxazole-4-carbonyl chloride. ##STR00001##

A compound, having a structure represented by a formula (I),

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and prepared by one pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.

A compound, having a structure represented by a formula (I),

##STR00001##

and prepared by one pot synthesis of benzophenone hydrazone, 7-chloroisatin, and copper(II) acetate monohydrate, and refluxing in 100 mL of anhydrous methanol solvent for 48 hrs. A method for preparing the compound includes: collecting and placing 0.0235 g of benzophenone hydrazone, 0.6914 g of 7-chloroisatin, and 0.6720 g of copper(II) acetate monohydrate complex in a 100.0 mL flask; adding 50 mL of anhydrous methanol as a solvent; stirring a resulting mixture at room temperature for 48 hrs; performing column chromatography separation, and elution with petroleum ether/dichloromethane in a volume ratio of 1:1, and collecting final component points and naturally volatilizing the final component points to obtain 7(E)-chloro-3-diphenylmethylindolin-2-one crystals. The compound is used as a catalyst for reaction between benzophenone imine and trimethylsilonitrile, and has a catalytic effect with a conversion rate reaching 99%.

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

A process for converting caprolactam to aminocapronitrile, the process comprising contacting a caprolactam feed with ammonia and an aluminosilicate zeolite catalyst to produce an aminocapronitrile product, wherein the catalyst comprises less than 5 wt. % of an active metal, and wherein conversion is greater than 50% and selectivity for aminocapronitrile is greater than 91%.

A process for converting caprolactam to aminocapronitrile, the process comprising contacting a caprolactam feed with ammonia and an aluminosilicate zeolite catalyst to produce an aminocapronitrile product, wherein the catalyst comprises less than 5 wt. % of an active metal, and wherein conversion is greater than 50% and selectivity for aminocapronitrile is greater than 91%.

A process for converting caprolactam to aminocapronitrile, the process comprising contacting a caprolactam feed with ammonia and an aluminosilicate zeolite catalyst to produce an aminocapronitrile product, wherein the catalyst comprises less than 5 wt. % of an active metal, and wherein conversion is greater than 50% and selectivity for aminocapronitrile is greater than 91%.

A column includes a column head, a column sump and a tube-shaped column shell disposed therebetween, two or more reaction zones lying above each other which each accommodate a catalyst bed, in which catalyst beds chlorosilanes disproportionate into low-boiling silanes, which form an ascending stream of gas, and also into high-boiling silanes which form a downwardly directed stream of liquid, within the column shell and along the column axis, two or more rectificative separation zones, the reaction zones and the separation zones alternate along the column axis, the separation zones are configured such that the stream of gas and the stream of liquid meet in the separation zones, and the reaction zones are configured such that the downwardly directed stream of liquid is led through the catalyst beds, whereas the upwardly directed stream of gas passes the catalyst beds in spatial separation from the stream of liquid.

A process for converting caprolactam to aminocapronitrile (ACN), the process comprising contacting a caprolactam feed stream with ammonia to produce a first crude product stream; separating the first crude product stream to produce an intermediate product stream comprising ACN and caprolactam recovery stream; and purifying the intermediate product stream to produce a purified product stream comprising greater than 95 wt % aminocapronitrile.