The present invention relates to novel processes for producing bis[3-isopropenyl-,-dimethylbenzyl]carbodiimide, to the thus-produced bis[3-isopropenyl-,-dimethylbenzyl]carbodiimide and to the use thereof as a hydrolysis inhibitor in polyurethane (PU)-based systems, preferably thermoplastic TPU, PU adhesives, PU casting resins, PU elastomers or PU foams.

The present invention relates to novel processes for producing bis[3-isopropenyl-,-dimethylbenzyl]carbodiimide, to the thus-produced bis[3-isopropenyl-,-dimethylbenzyl]carbodiimide and to the use thereof as a hydrolysis inhibitor in polyurethane (PU)-based systems, preferably thermoplastic TPU, PU adhesives, PU casting resins, PU elastomers or PU foams.

A method for producing a peptide compound by a solid phase method, the method comprising: a preparation step of preparing a first amino acid having an amino group or a first peptide having an amino group supported on a solid phase; and a condensation step of condensing the first amino acid or first peptide, and a second amino acid having a protected amino group and/or protected hydroxy group and a carboxy group, or a second peptide having a protected amino group and/or protected hydroxy group and a carboxy group in the presence of a predetermined carbodiimide-based condensing agent and an additive.

A method for producing a peptide compound by a solid phase method, the method comprising: a preparation step of preparing a first amino acid having an amino group or a first peptide having an amino group supported on a solid phase; and a condensation step of condensing the first amino acid or first peptide, and a second amino acid having a protected amino group and/or protected hydroxy group and a carboxy group, or a second peptide having a protected amino group and/or protected hydroxy group and a carboxy group in the presence of a predetermined carbodiimide-based condensing agent and an additive.

A polyalkylene glycol terminated poly-carbodiimide has formula 1: ##STR00001##
R.sub.1 is an aliphatic group from about 5 to about 12 carbon atoms, a cycloaliphatic moiety of from about 6 to about 20 carbon atoms, an isosorbide moiety, a 1,3-furan moiety, an L-lysine alkyl ester moiety, a rosin moiety, a cycloaliphatic unsaturated moiety, or a cardanol moiety; R.sub.2 is hydrogen or a methyl group; R.sub.3 is a methyl, ethyl, or propyl moeity; and n and m are integers and are each independently between 1 and about 30.

A polyalkylene glycol terminated poly-carbodiimide has formula 1: ##STR00001##
R.sub.1 is an aliphatic group from about 5 to about 12 carbon atoms, a cycloaliphatic moiety of from about 6 to about 20 carbon atoms, an isosorbide moiety, a 1,3-furan moiety, an L-lysine alkyl ester moiety, a rosin moiety, a cycloaliphatic unsaturated moiety, or a cardanol moiety; R.sub.2 is hydrogen or a methyl group; R.sub.3 is a methyl, ethyl, or propyl moeity; and n and m are integers and are each independently between 1 and about 30.

A polyalkylene glycol terminated poly-carbodiimide has formula 1:

##STR00001##

R.sub.1 is an aliphatic group from about 5 to about 12 carbon atoms, a cycloaliphatic moiety of from about 6 to about 20 carbon atoms, an isosorbide moiety, a 1,3-furan moiety, an L-lysine alkyl ester moiety, a rosin moiety, a cycloaliphatic unsaturated moiety, or a cardanol moiety; R.sub.2 is hydrogen or a methyl group; R.sub.3 is a methyl, ethyl, or propyl moeity; and n and m are integers and are each independently between 1 and about 30.

A polyalkylene glycol terminated poly-carbodiimide has formula 1:

##STR00001##

R.sub.1 is an aliphatic group from about 5 to about 12 carbon atoms, a cycloaliphatic moiety of from about 6 to about 20 carbon atoms, an isosorbide moiety, a 1,3-furan moiety, an L-lysine alkyl ester moiety, a rosin moiety, a cycloaliphatic unsaturated moiety, or a cardanol moiety; R.sub.2 is hydrogen or a methyl group; R.sub.3 is a methyl, ethyl, or propyl moeity; and n and m are integers and are each independently between 1 and about 30.