The invention provides methods of synthesizing compounds in an asymmetric or enantioenriched fashion, wherein the compounds are useful intermediates in the synthesis of viral protease inhibitors.

A polycarbamate comprising having less than 5 wt % total of biuret, cyanuric acid, and polyallophanate; and has a Gardner level of equal or greater than 3 is provided. A coating comprising the polycarbamate is also provided.

A polycarbamate comprising having less than 5 wt % total of biuret, cyanuric acid, and polyallophanate; and has a Gardner level of equal or greater than 3 is provided. A coating comprising the polycarbamate is also provided.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril, inter alia via nitro 5 compounds. It further relates to new intermediate compounds and their use for said new chemical synthesis route, as well as a new catalyst ligand.

The present invention aims to provide a new method for producing an indole compound or a salt thereof, which has an ITK inhibitory action, and is useful for the prophylaxis or treatment of inflammatory disease.

The present invention is a method for producing N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-(2S)-2-(morpholin-4-yl)propanamide, which comprises a step of reacting

##STR00001##

The present invention aims to provide a new method for producing an indole compound or a salt thereof, which has an ITK inhibitory action, and is useful for the prophylaxis or treatment of inflammatory disease.

The present invention is a method for producing N-[2-(6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-3-yl)-1H-indol-6-yl]-N-methyl-(2S)-2-(morpholin-4-yl)propanamide, which comprises a step of reacting

##STR00001##

A foaming agent comprising organic amine salt compounds of the following general formula A.sup.n [B.sup.m+].sub.p (I) is disclosed, wherein A.sup.n is a CO.sub.2-donating anion with a valence of n, wherein n=1, 2 or 3; each B.sup.m+ comprises: ammonium ion and/or organic amine (B) cation, wherein

[00001]$m=1.Math.\text{-10;}.Math..Math.0<p\frac{n}{m};$

and wherein A.sup.n is one or more selected from following anions: (a) carbamate; (b) carbonate; (c) formate; (d) bicarbonate radical; (e) organic mono carbonate; (f) organic radical multi-carbamate; (g) orthoformate; or (h) organic radical poly-carbonate. The compound of the general formula (I) has at least one of hydroxyalkyl group linked to N atom, i.e., has alkanolamine residue. They can be used as polyurethane foaming agent, polystyrene foaming agent or polyvinyl choride foaming agent.

The present invention pertains to new methods for generating energy and useful nitrogen compounds from captured carbon dioxide. It involves employing an osmotic engine, draw solution, and feed solution. An osmotic gradient between the solutions assists in generating energy and a solution of ammonium carbonate, ammonium bicarbonate or mixture thereof. This solution may be decomposed to form ammonia, carbon dioxide, a precipitate, or a mixture thereof.

The present invention pertains to new methods for generating energy and useful nitrogen compounds from captured carbon dioxide. It involves employing an osmotic engine, draw solution, and feed solution. An osmotic gradient between the solutions assists in generating energy and a solution of ammonium carbonate, ammonium bicarbonate or mixture thereof. This solution may be decomposed to form ammonia, carbon dioxide, a precipitate, or a mixture thereof.