C07C275/00

Biaryl urea derivative or salt thereof and preparation process and use for the same
10647665 · 2020-05-12 · ·

The present invention discloses a biaryl urea RORt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORt-related disease. ##STR00001##

Azole derivatives for corrosion mitigation

Anticorrosion compounds and compositions can be used in methods for preventing metal corrosion. More specifically, the method comprises contacting an anticorrosion composition to an aqueous system in contact with a metal. The anticorrosion composition comprises substituted and/or hydrogenated benzotriazoles and tolyltriazoles.

METHOD FOR GRANULATING UREA

Precipitation of an ammonium salt is prevented while suppressing an increase in water content of the aqueous urea solution which is to be supplied to a urea granulation step, when recovering and using urea and NH.sub.3 in a gas which contains urea dust and NH.sub.3 and which arises from a urea granulation step. Provided is a method for granulating urea including a granulation step of producing granular solid urea from a feed aqueous urea solution by using air; a recovery step of recovering urea dust and NH.sub.3 from air discharged from the granulation step, by use of an aqueous solution containing an acid, so as to obtain a recovered solution containing urea and an ammonium salt; a salt concentration adjustment step of mixing the recovered solution with an aqueous urea solution having a lower ammonium salt concentration than the recovered solution, so as to adjust the ammonium salt concentration of the recovered solution; a concentration step of concentrating the solution obtained from the salt concentration adjustment step by vaporizing water contained in the solution obtained from the salt concentration adjustment step, so as to obtain a concentrated recovered solution; and a mix step of mixing the concentrated recovered solution with the feed aqueous urea solution, wherein the ammonium salt concentration of the concentrated recovered solution is 7 mass % or less.

METHOD FOR GRANULATING UREA

Precipitation of an ammonium salt is prevented while suppressing an increase in water content of the aqueous urea solution which is to be supplied to a urea granulation step, when recovering and using urea and NH.sub.3 in a gas which contains urea dust and NH.sub.3 and which arises from a urea granulation step. Provided is a method for granulating urea including a granulation step of producing granular solid urea from a feed aqueous urea solution by using air; a recovery step of recovering urea dust and NH.sub.3 from air discharged from the granulation step, by use of an aqueous solution containing an acid, so as to obtain a recovered solution containing urea and an ammonium salt; a salt concentration adjustment step of mixing the recovered solution with an aqueous urea solution having a lower ammonium salt concentration than the recovered solution, so as to adjust the ammonium salt concentration of the recovered solution; a concentration step of concentrating the solution obtained from the salt concentration adjustment step by vaporizing water contained in the solution obtained from the salt concentration adjustment step, so as to obtain a concentrated recovered solution; and a mix step of mixing the concentrated recovered solution with the feed aqueous urea solution, wherein the ammonium salt concentration of the concentrated recovered solution is 7 mass % or less.

CROSSLINKING COMPONENT FOR BINDER RESINS

This invention relates to a crosslinking component for binder resins which is especially suitable to be used together with epoxy-group containing binders and/or (poly)isocyanates such as blocked (poly)isocyanates and which comprises at least two blocked isocyanate groups per molecule of the crosslinking component whereby at least one of the at least two blocked isocyanate groups is a group according to structural unit (I), wherein the ratio of structural units of formula (II), if present, to structural units of formula (I) is 0.40 or below. The cross-linking component may also be self-cross-linkable. The present invention further relates to a coating composition, e.g. a one-component coating composition comprising the crosslinking component and a method of its manufacture.

CROSSLINKING COMPONENT FOR BINDER RESINS

This invention relates to a crosslinking component for binder resins which is especially suitable to be used together with epoxy-group containing binders and/or (poly)isocyanates such as blocked (poly)isocyanates and which comprises at least two blocked isocyanate groups per molecule of the crosslinking component whereby at least one of the at least two blocked isocyanate groups is a group according to structural unit (I), wherein the ratio of structural units of formula (II), if present, to structural units of formula (I) is 0.40 or below. The cross-linking component may also be self-cross-linkable. The present invention further relates to a coating composition, e.g. a one-component coating composition comprising the crosslinking component and a method of its manufacture.

BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME
20190248737 · 2019-08-15 ·

The present invention discloses a biaryl urea RORt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORt-related disease.

##STR00001##

BIARYL UREA DERIVATIVE OR SALT THEREOF AND PREPARATION PROCESS AND USE FOR THE SAME
20190248737 · 2019-08-15 ·

The present invention discloses a biaryl urea RORt inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an RORt inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an RORt-related disease.

##STR00001##

Compositions comprising free-standing two-dimensional nanocrystals

The present invention is directed to compositions comprising at least one layer or at least two layers, each layer comprising a substantially two-dimensional array of crystal cells, having first and second surfaces, each crystal cell having the empirical formula of M.sub.n+1X.sub.n, where M, X, and n are described in the specification, and devices incorporating these compositions.

Compositions comprising free-standing two-dimensional nanocrystals

The present invention is directed to compositions comprising at least one layer or at least two layers, each layer comprising a substantially two-dimensional array of crystal cells, having first and second surfaces, each crystal cell having the empirical formula of M.sub.n+1X.sub.n, where M, X, and n are described in the specification, and devices incorporating these compositions.