Provided are a novel indene-based transition metal complex, a transition metal catalyst composition including the same having high catalyst activity for preparing an ethylene homopolymer or copolymers of ethylene and one or more -olefins, a method for preparing an ethylene homopolymer or copolymers of ethylene and -olefins using the same, and the thus-prepared ethylene homopolymer or copolymers of ethylene and -olefins.

Provided herein are broad-spectrum G-Protein coupled receptor (GPCR) binding agents, detectable/isolatable compounds comprising such binding agents (e.g., broad-spectrum GPCR binding agents linked to a functional element and/or solid surface), and methods of use thereof for the detection/isolation of GPCRs.

Provided herein are broad-spectrum G-Protein coupled receptor (GPCR) binding agents, detectable/isolatable compounds comprising such binding agents (e.g., broad-spectrum GPCR binding agents linked to a functional element and/or solid surface), and methods of use thereof for the detection/isolation of GPCRs.

In one aspect, described herein is an intronic recognition element for splicing modifier (iREMS) that can be recognized by a compound provided herein. In another aspect, described herein are methods for modulating the amount of a product of a gene, wherein a precursor RNA transcript transcribed from the gene contains an intronic REMS, and the methods utilizing a compound described herein. More particularly, described herein are methods for modulating the amount of an RNA transcript or protein product encoded by a gene, wherein a precursor RNA transcript transcribed from the gene comprises an intronic REMS, and the methods utilizing a compound described herein. In another aspect, provided herein are artificial gene constructs comprising an intronic REMS, and uses of those artificial gene constructs to modulate protein production. In another aspect, provided herein are methods for altering endogenous genes to comprise an intronic REMS, and the use of a compound described herein to modulate protein produced from such altered endogenous genes.

Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Compositions and methods are provided for the inhibition of the function of RNA guided endonucleases, including the identification and use of such inhibitors.

Novel Styryl Carboxylate derivatives are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases, and diabetes.

Novel Styryl Carboxylate derivatives are provided which exhibit activity for the treatment of immunological diseases, inflammation, obesity, hyperlipidemia, hypertension, neurological diseases, and diabetes.

The present invention relates to a terminal modified and conjugated diene-based polymer rubber composition including a terminal modified and conjugated diene-based polymer which is characterized in that an aminosilane-based terminal modifier represented by Formula 1 or Formula 2 is combined at the terminal of a conjugated diene-based polymer, and a method for preparing the same.

The present invention relates to a terminal modified and conjugated diene-based polymer rubber composition including a terminal modified and conjugated diene-based polymer which is characterized in that an aminosilane-based terminal modifier represented by Formula 1 or Formula 2 is combined at the terminal of a conjugated diene-based polymer, and a method for preparing the same.