The present invention relates to a terminal modified and conjugated diene-based polymer rubber composition including a terminal modified and conjugated diene-based polymer which is characterized in that an aminosilane-based terminal modifier represented by Formula 1 or Formula 2 is combined at the terminal of a conjugated diene-based polymer, and a method for preparing the same.

The invention concerns use of metal scavengers of the formula (1), wherein the variables are as defined in the description of the invention, for removal of ruthenium residues, compounds, or complexes thereof, from the post-reaction mixtures, from the products of reactions catalyzed with ruthenium complexes, as well as from organic compounds contaminated with ruthenium. ##STR00001##

The present disclosure provides a vinylation coupled derivative of -elemene, and a preparation method and use thereof in preparation of an antitumor drug. The present disclosure provides a vinylation coupled derivative of -elemene having a structure shown in Formula (I), a pharmaceutical composition and a hydrate including a compound shown in Formula (I), as well as an isotopic derivative, a chiral isomer, a variant, a salt, a prodrug, and a preparation of the compound shown in Formula (I). The present disclosure further provides a preparation method and use of the vinylation coupled derivative of -elemene, and an inhibitory activity of the derivative on proliferation of various tumor cell lines. The vinylation coupled derivative of -elemene is expected to be an antitumor drug candidate for treating colon cancer and lung cancer.

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The present disclosure provides a vinylation coupled derivative of -elemene, and a preparation method and use thereof in preparation of an antitumor drug. The present disclosure provides a vinylation coupled derivative of -elemene having a structure shown in Formula (I), a pharmaceutical composition and a hydrate including a compound shown in Formula (I), as well as an isotopic derivative, a chiral isomer, a variant, a salt, a prodrug, and a preparation of the compound shown in Formula (I). The present disclosure further provides a preparation method and use of the vinylation coupled derivative of -elemene, and an inhibitory activity of the derivative on proliferation of various tumor cell lines. The vinylation coupled derivative of -elemene is expected to be an antitumor drug candidate for treating colon cancer and lung cancer.

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