Patent classifications
C07C381/00
(2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES
A compound, or pharmaceutically acceptable salt thereof, having a formula I of:
##STR00001## wherein R.sup.1 is H or optionally-substituted alkyl; R.sup.2 is optionally-substituted alkyl; R.sup.3 and R.sup.4 are each independently H or optionally-substituted alkyl; R.sup.5 is H, optionally-substituted alkyl, acyl, or alkoxycarbonyl; R.sup.6 and R.sup.7 are each independently H, deuterium, optionally-substituted alkyl, or R.sup.6 and R.sup.7 together form a carbocyclic; R.sup.8 is optionally-substituted thiazolyl, optionally-substituted thiophenyl, or substituted phenyl, provided that if R.sup.8 is 4-halophenyl, then R.sup.2 is substituted alkyl or branched alkyl or at least one of R.sup.6 or R.sup.7 is not H; and R.sup.30, R.sup.31 and R.sup.32 are each independently H, deuterium, halogen, substituted sulfanyl, or optionally-substituted alkoxy.
COMPOUNDS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).
##STR00001##
COMPOUNDS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
Novel compounds of formula (II) are disclosed. Compounds of formula (II) comprise ornithine derivatives or compounds that may metabolize to ornithine. Also disclosed are methods for the treatment of neurodegenerative diseases such as Alzheimer's Disease using compounds of formula (II).
##STR00001##
HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF
The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
##STR00001##
HYDROGEN SULFIDE PRECURSORS AND CONJUGATES THEREOF
The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.
##STR00001##
MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).
##STR00001##
MOLECULES HAVEING PESTICIDAL UTILIY AND INTERMEDIATES, COMPOSITIONS AND PROCESSES RELATED THERETO
This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (Formula One).
##STR00001##
MERCAPTOACETOPHENONE AMINOHYDRAZONES, THEIR SALTS AND USES THEREOF
A new class of antibiotics, namely, mercaptoacetophenone aminohydrazones, their analogues, their method of preparation, their salts, and their use in cases of bacterial infections, either alone or with other compounds.
MERCAPTOACETOPHENONE AMINOHYDRAZONES, THEIR SALTS AND USES THEREOF
A new class of antibiotics, namely, mercaptoacetophenone aminohydrazones, their analogues, their method of preparation, their salts, and their use in cases of bacterial infections, either alone or with other compounds.
Methods for producing sulfonic acid diamides
The present invention relates to a process for preparing sulfuric diamides of the general formula I
R.sup.1R.sup.2NS(O).sub.2NH.sub.2(I)
in which R.sup.1 and R.sup.2 are each independently a primary alkyl radical having from 1 to 8 carbon atoms, a secondary alkyl radical having from 3 to 8 carbon atoms or a cycloalkyl radical having from 5 to 8 carbon atoms, or, together with the nitrogen atom, form a 5- to 8-membered, saturated nitrogen heterocycle which, as well as the nitrogen atom, may have a further heteroatom selected from O and S as a ring member, where the nitrogen heterocycle is unsubstituted or may have 1, 2, 3 or 4 alkyl groups having in each case from 1 to 4 carbon atoms as substituents. The process comprises the following steps: i) the reaction of a secondary amine of the formula II
R.sup.1R.sup.2NH(II) in which R.sup.1 and R.sup.2 are each as defined above with sulfuryl chloride in an inert solvent, especially an aromatic solvent, in the presence of a tertiary amine to give a sulfamoyl chloride of the formula III
R.sup.1R.sup.2NS(O).sub.2Cl(III) in which R.sup.1 and R.sup.2 are each as defined above, and ii) reaction of the sulfamoyl chloride of the formula III obtained in step i) with ammonia,
the sulfamoyl chloride of the formula III being used in step ii) in the form of the solution obtained in step i) in the inert solvent, especially the aromatic solvent.