The present invention provides synthetic methods and preparation of cholecalciferol (vitamin D.sub.3) from cholesterol, which is a by-product of the Omega-3 oil production process. According to the invention, dehydro-cholesterol is prepared and subjected to UV radiation (254 nm). Accordingly, two new synthetic alternatives are provided; wherein the first consists of processes of oxidation-reduction of cholesterol to form dehydro-cholesterol and subsequent UV radiation; which route involves six steps (see scheme 1). The second transformation involves the generation of vitamin D.sub.3 by means of a bromination method and a photocatalytic reaction using UV radiation; which alternative requires four steps (see scheme 2).

The present invention provides synthetic methods and preparation of cholecalciferol (vitamin D.sub.3) from cholesterol, which is a by-product of the Omega-3 oil production process. According to the invention, dehydro-cholesterol is prepared and subjected to UV radiation (254 nm). Accordingly, two new synthetic alternatives are provided; wherein the first consists of processes of oxidation-reduction of cholesterol to form dehydro-cholesterol and subsequent UV radiation; which route involves six steps (see scheme 1). The second transformation involves the generation of vitamin D.sub.3 by means of a bromination method and a photocatalytic reaction using UV radiation; which alternative requires four steps (see scheme 2).

The present disclosure relates to biomimetic nanomaterials, compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).

The present disclosure relates to biomimetic nanomaterials, compounds, compositions, and methods for delivery of therapeutic, diagnostic, or prophylactic agents (for example, a nucleic acid).

The present invention relates to new vitamin D compounds which are bonded to a labelling group at the C3 stereocentre by means of a linker. The present invention further relates to a method for producing these vitamin D compounds and to the use of an intermediate for producing these compounds. The present invention also relates to a method for quantitatively determining vitamin D using a vitamin D compound according to the invention as a tracer. Furthermore, the present invention relates to a reagent for determining vitamin D, containing a compound according to the invention, and to the use thereof for determining vitamin D.

The present invention relates to new vitamin D compounds which are bonded to a labelling group at the C3 stereocentre by means of a linker. The present invention further relates to a method for producing these vitamin D compounds and to the use of an intermediate for producing these compounds. The present invention also relates to a method for quantitatively determining vitamin D using a vitamin D compound according to the invention as a tracer. Furthermore, the present invention relates to a reagent for determining vitamin D, containing a compound according to the invention, and to the use thereof for determining vitamin D.

This present disclosure is directed to novel prodrugs of activated vitamin D.sub.3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.

This present disclosure is directed to novel prodrugs of activated vitamin D.sub.3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the enzyme CYP24, low calcemic activity, and anti-proliferative activity. Specifically, these prodrugs are 1-deoxy prohormones of active Vitamin D analogs, e.g. analogs of calcitriol. This disclosure is also directed to pharmaceutical and diagnostic compositions containing the prodrugs of the invention, and to their medical use, particularly as prodrugs in the treatment and/or prevention of diseases.

Compounds include carbamate derivatives of vitamin D including vitamin D.sub.3 and vitamin D.sub.2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.

Compounds include carbamate derivatives of vitamin D including vitamin D.sub.3 and vitamin D.sub.2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.