Patent classifications
C07D209/00
Polycyclic compound acting as IDO inhibitor and/or IDO-HDAC dual inhibitor
Compounds as IDO inhibitors and/or dual inhibitors of IDO-HDAC are described. Specifically, the compounds represented by the following formula (I) are described, wherein each group is defined as described in the specification. The compounds have IDO inhibitory activity or IDO-HDAC dual inhibitory activity and can be used for preventing or treating diseases associated with IDO and/or IDO-HDAC activity or expression levels. At the same time, the compounds of the present invention can be combined with an anti-tumor antibody such as PD-1 and PD-L1, and such a combination can greatly increase the anti-tumor response rate of the antibody and broaden the types of tumors to be treated. ##STR00001##
Benzene fused heterocyclic derivative and pharmaceutical composition comprising the same
The present disclosure provides a benzene fused heterocyclic derivative of Formula (I): is a single or double bond; n is an integer of 0 or 1; A is —CH.sub.2—, —CH(OH)—, or —C(O)—; G is C or N; X is —CH.sub.2—, O, or —C(O)—; Y is alkyl, aryl, or heterocyclic alkyl optionally substituted with at least one substituent independently selected from a group consisting of: H, halogen, alkyl, alkyl substituted with at least one halogen, aryl, aryl substituted with at least one halogen, —NR.sub.y1R.sub.y2, —OR.sub.y1, —R.sub.y1C(O)R.sub.y3, —C(O)R.sub.y1, —C(O)OR.sub.y2, —C(O)OR.sub.y2Ry3, —NR.sub.y1C(O)R.sub.y2, —NR.sub.y1C(O)NR.sub.y2R.sub.y3, —NR.sub.y1C(O)OR.sub.y2R.sub.y3, —NR.sub.y1C(O)R.sub.y2OR.sub.y3, C(O)NR.sub.y1(R.sub.y2R.sub.y3), —C(O)NR.sub.y1(R.sub.y2OR.sub.y1), —OR.sub.y2R.sub.y3, and —OR.sub.y2OR.sub.y3, wherein each of R.sub.y1 and R.sub.y2 is independently selected from a group consisting of H, oxygen, alkyl, and aryl, and R.sub.y3 is aryl optionally substituted with at least one halogen; Z is —NR.sub.z1R.sub.z2, —NR.sub.z1R.sub.z3, —OR.sub.z1, —OR.sub.z1R.sub.z3, —C(O)R.sub.z1R.sub.z3, —C(O)OR.sub.z1R.sub.z3, —NR.sub.z1C(O)R.sub.z2R.sub.z3, —NR.sub.z1C(O)OR.sub.z2R.sub.z3, —C(O)NR.sub.z1R.sub.z3, or OR.sub.z2OR.sub.z3, wherein each of R.sub.z1 and R.sub.z2 is independently selected from a group consisting of H, oxygen, alkyl and aryl, and R.sub.z3 is aryl optionally substituted with at least one substituent independently selected from a group consisting of halogen, OH, —R.sub.zaCOOR.sub.zb, —OR.sub.zaCOOR.sub.zb, —R.sub.zaSO.sub.2R.sub.zb, —R.sub.zaSO.sub.2NR.sub.zbR.sub.zcR.sub.zd, —R.sub.zaC(O)R.sub.zbR.sub.zc, —R.sub.zaC(O)NR.sub.zbR.sub.zcR.sub.zd, —RZ.sub.aC(O)NR.sub.zbSO.sub.2R.sub.zc, wherein Rza is nil or alkyl, R.sub.zb is H or alkyl, each of R.sub.zb and R.sub.zc is independently selected from a group consisting of H, OH, alkyl, aryl, alkoxyl, or NR.sub.zbR.sub.zc is a nitrogen-containing heterocyclic alkyl ring, R.sub.zd is nil or a sulfonyl alkyl group. ##STR00001##
POLARIZING FILM WITH ADHESIVE LAYER, AND LIQUID CRYSTAL DISPLAY DEVICE
Provided is a polarizing film with a pressure-sensitive adhesive layer that can contribute to the widening of the color gamut of an image display apparatus, the polarizing film with a pressure-sensitive adhesive layer being suppressed in brightness reduction and being excellent in durability. The polarizing film with a pressure-sensitive adhesive layer of the present invention includes a polarizer and a pressure-sensitive adhesive layer arranged on at least one side of the polarizer. A distance between the polarizer and the pressure-sensitive adhesive layer is 25 μm or less. The pressure-sensitive adhesive layer has an absorption peak in a wavelength band in the range of from 580 nm to 610 nm. The pressure-sensitive adhesive layer contains a compound X represented by the general formula (I) or the general formula (II).
OPTICALLY FUNCTIONAL FILM
Provided is an optically functional film that can contribute to the widening of the color gamut of an image display apparatus, the optically functional film being suppressed in brightness reduction and being excellent in durability. The optically functional film of the present invention includes an optically functional layer having a moisture permeability of 100 g/m.sup.2 or less, wherein the optically functional layer has an absorption peak in a wavelength band in a range of from 580 nm to 610 nm, and wherein the optically functional layer contains a compound X represented by the general formula (I) or the general formula (II).
TRIAZOLOPYRIMIDINES, THEIR PREPARATION AND USE
The present invention provides a compound having the structure:
##STR00001##
wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, and R.sub.5 are each independently H, halogen, CF.sub.3, C.sub.1-C.sub.4 alkyl, aryl or heteroaryl; X is N or CR.sub.6, wherein R.sub.6 is H, OH, or halogen; A is absent or present, and when present is
##STR00002##
B has the structure:
##STR00003##
or a pharmaceutically acceptable salt thereof.
OPTICALLY FUNCTIONAL FILM
Provided is an optically functional film that can contribute to the widening of the color gamut of an image display apparatus, the optically functional film being suppressed in brightness reduction and being excellent in durability. The optically functional film of the present invention includes: a resin layer; and a pressure-sensitive adhesive layer arranged on at least one side of the resin layer, wherein the resin layer and/or the pressure-sensitive adhesive layer contains, as coloring matters, a compound X represented by the general formula (I) or (II) and a compound Y having an absorption peak in a wavelength band in a range of from 400 nm to 700 nm, which are mixed with each other.
SQUARYLIUM COMPOUNDS FOR USE IN DISPLAY DEVICES
Described herein are embodiments of squarylium compounds for use as filters in light-emitting and/or display devices. One problem of known quarylium dyes is that strong nucleophiles can attack the electron-deficient cyclobutene ring which can lead to a loss of the dye's colour. Another potential drawback with squaraine dyes can be their tendency to form aggregates, which can lead to a substantial broadening of their absorption bands. Use of the present compounds in filters address these problems. The squarylium compounds of the present invention have the following formulas:
##STR00001##
CIRCULARLY POLARIZING PLATE
Provided is a circularly polarizing plate that is excellent in antireflection characteristic, and that can be produced at low cost. The circularly polarizing plate of the present invention includes in the stated order: a polarizer; a retardation layer (20a) configured to function as a /4 plate; and a colored layer, wherein an angle formed by an absorption axis of the polarizer and a slow axis of the retardation layer (20a) is from 35 to 55, wherein the colored layer has an absorption peak in a wavelength band in a range of from 580 nm to 610 nm, and wherein the colored layer contains a compound X represented by the general formula (I) or the general formula (II).
COMPOUND AND PHOTOELECTRIC DEVICE, IMAGE SENSOR AND ELECTRONIC DEVICE INCLUDING THE SAME
A compound of Chemical Formula 1, and an organic photoelectric device, an image sensor, and an electronic device including the same are disclosed:
##STR00001##
In Chemical Formula 1, each substituent is the same as defined in the detailed description.
OPTICAL LAYERED BODY
Provided is an optical laminate having the following feature: when the optical laminate is used in an image display apparatus, the optical laminate can express a sufficient brightness, can express a satisfactory hue, and can achieve a cost reduction while suppressing a reflectance. The optical laminate of the present invention includes: a wavelength conversion layer; and an absorption layer arranged on one side of the wavelength conversion layer, wherein the absorption layer has an absorption peak in a wavelength band in a range of from 580 nm to 610 nm, and wherein the absorption layer contains a compound x represented by the general formula (I) or the general formula (II).