Provided are macrocyclic compounds having one or more transmembrane segment-thermoresponsive segment moiety. Also provided are dimers comprising two macrocyclic units, which have one or more transmembrane segment-thermoresponsive segment moiety, joined by one or more crosslinking moieties. The macrocyclic compounds and macrocyclic units have a macrocyclic backbone comprise alternating alpha amino acid and meta-aminobenzoic acid moieties. The macrocyclic compounds and dimers can be used to deliver a cargo (e.g., cell-interacting agents such as, for example, drugs and cryoprotectants) to, for example, an organ, tissue, or an individual, A cargo may be encapsulated in lipid vesicles.

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

The present invention relates to complexes of nocardamine (desferrioxamine E) with at least one metal, specifically with Zn.sup.2+ or Ga.sup.3+ or silver or gold or any combinations thereof. The invention further provides procedures for the preparation of the complexes and pharmaceutical compositions comprising said complexes or any combinations of said complexes, as well as methods using the compositions and complexes of the invention in modulating cytokine levels in a subject and thereby treating inflammation-associated disorders.

Methods of making a compound according to the following scheme: ##STR00001##
wherein: R.sub.1 is a side chain of an amino acid residue selected from Ala, Ser, Thr and Leu; R.sub.2 is a side chain of an amino acid residue selected from Asp, Glu, Gln and Asn; [Aaa] is an amino acid residue selected from Ser, Asp, Ala, Ile, Phe, Trp, Lys, Glu and Thr; R.sub.3 is hydrogen or alkyl; Each of R.sub.4 and R.sub.4 independently is hydrogen or alkyl; Both R.sub.a and R.sub.a are hydrogen; or together are an oxo(O) group; Both R.sub.b and R.sub.b are hydrogen; or together are an oxo (O) group; L is ##STR00002## X is CH.sub.2, O or S; R.sub.5 is hydrogen or alkyl; m is an integer from 1 to 3; and n is an integer from 2 to 20.

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

The present disclosure generally relates to scavenging hydrogen sulfide. The disclosure pertains to non-aqueous and non-volatile compositions that include a monolignol alcohol and hydrogen sulfide scavenging compound. The hydrogen sulfide scavenging compound may be hexamine in some aspects. The compositions may also include a C.sub.2-8 polyol. The compositions disclosed are stable and can be used, for example, in removing hydrogen sulfide from hot asphalt.

The present invention discloses compounds that are useful in the treatment of respiratory diseases of animals, especially Bovine or Swine Respiratory disease (BRD and SRD).

An antimicrobial coating system and method are described. In some embodiments, a system may include a composition. The composition may include one or more bridged polycyclic compounds. At least one of the bridged polycyclic compounds may include at least two cyclic groups, and at least two of the cyclic groups may include quaternary ammonium moieties. In some embodiments, a method may include applying an antimicrobial coating to an oral surface, a surface of a construction substrate, a surface of a marine substrate, a surface of a medical device, or a surface of a personal care device. The protective coating may be antimicrobial. A protective coating may include antimicrobial bridged polycyclic compounds. Bridged polycyclic compounds may include quaternary ammonium compounds. Bridged polycyclic compounds based coating systems may impart self-cleaning properties to a surface (e.g., a tooth surface).