Patent classifications
C07D313/00
CHLOROTONIL DERIVATIVES
The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
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CHLOROTONIL DERIVATIVES
The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria.
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Chlorotonil derivatives
The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria. ##STR00001##
Chlorotonil derivatives
The present invention relates to novel chlorotonil derivatives of formula (I) and the use thereof for the treatment or prophylaxis of bacterial infections and malaria. ##STR00001##
Splicing modulator antibody-drug conjugates and methods of use
Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
Splicing modulator antibody-drug conjugates and methods of use
Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
DERIVATIVES OF 10-METHYLENE LIPIDS, PROCESS FOR PREPARING SUCH DERIVATIVES AND USE THEREOF
The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.
DERIVATIVES OF 10-METHYLENE LIPIDS, PROCESS FOR PREPARING SUCH DERIVATIVES AND USE THEREOF
The present invention relates to derivatives of 10-methylene lipids, their preparation and their use.
PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY
This disclosure relates to picolinamides of Formula I and their use as fungicides.
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PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY
This disclosure relates to picolinamides of Formula I and their use as fungicides.
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