Trisubstituted bicyclic heterocyclic compounds (e.g., chromenones and quinolines) and pharmaceutical compositions,that modulate kinase activity, including PI3 kinase activity, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

This invention is in the fields of immunology and autoimmunity. More particularly it concerns pharmaceutical compositions comprising compounds which are useful agents for inhibiting the functions of TIP60 and the use of such compounds in the treatment of an individual suffering, for example, from ulcerative colitis and other irritable bowel diseases.

Methods for preparing compounds having the following structure (I):

##STR00001##

or a pharmaceutically acceptable salt, stereoisomer, or tautomer thereof, wherein R.sup.1, R.sup.2a, R.sup.2b, R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b and R.sup.4c, are as defined herein are provided. Related compounds and methods for making the same are also provided.

The present invention provides a compound of Formula (I) or an agronomically acceptable salt thereof, wherein: R.sup.2 is selected from the group consisting of (A1), (A2) and (A3) wherein X.sup.1 is N or CR.sup.7X.sup.2 is N or CR.sup.8X.sup.3 is N or CR.sup.9X.sup.4 is N or CR.sup.6R.sup.1, R.sup.3, R.sup.4, R.sup.5 R.sup.6, R.sup.7, R.sup.8 and R.sup.9 are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), and to their use for controlling weeds, in particular in crops of useful plants. ##STR00001##

The present invention relates to tackifier compounds and methods of using the same. In various embodiments, the present invention provides a tackifier compound including independently substituted or unsubstituted fused rings A and B each independently chosen from (C.sub.5-C.sub.10)cycloalkyl and (C.sub.2-C.sub.10)heterocyclyl. Fused ring A is substituted with (R.sup.1).sub.1-8 and fused ring B is substituted with (OC(O)RC(O)R.sup.2).sub.1-8. At each occurrence R is independently chosen from (C.sub.2-C.sub.10)alkanylene, (C.sub.2-C.sub.10)alkenylene, (C.sub.2-C.sub.10)alkynylene, C.sub.5-C.sub.20(arylene), and (C.sub.1-C.sub.20)heteroarylene, wherein R is unsubstituted or substituted. At each occurrence R.sup.1 is independently selected from OH, OR.sup.3, and OC(O)RC(O)R.sup.2. At each occurrence R.sup.2 is independently chosen from OH, OR.sup.3, NH.sub.2, NHR.sup.3, and NR.sup.3.sub.2. At each occurrence R.sup.3 is independently chosen from (C.sub.1-C.sub.10)alkanyl, (C.sub.2-C.sub.10)alkenyl, (C.sub.2-C.sub.10)alkynyl, C.sub.5-C.sub.20(aryl), and (C.sub.1-C.sub.20)heteroaryl, wherein R.sup.3 is unsubstituted or substituted.

The present invention relates to secondary amines suitable for the preparation of ligands for organometallic complexes, their preparation and their use.

The present invention relates to compounds useful as inhibitors of PI3K, particularly of PI3K. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

The present invention relates to a process for preparing substituted anthranilic acid derivatives of the formula (I) ##STR00001##
in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each as defined in the description, by conversion of compounds of the general formula (IV) in the presence of a palladium catalyst and carbon monoxide. The present invention likewise relates to compounds of the general formula (IV). ##STR00002##

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not limited to leukemias and solid tumors, in mammals, especially humans.

A compound of formula ##STR00001##
wherein V, W, X and Y represent N or CH, at least one of V, W, X and Y being N and at least two of V, W, X and Y being CH; R.sub.1, R.sub.2 and R.sub.3 are each independently of the other hydrogen, C.sub.1-C.sub.8 alkyl, C.sub.1-C.sub.8 alkoxy, nitro, cyano, trifluoromethyl, halogen or hydroxy; and the compound provides good lightfastness properties to textile fibre materials, in particular PES fibre materials.