Patent classifications
C07D487/00
Use of TG02 for treating gliomas in pediatric subjects
The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g., a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3-mutated glioma (e.g., a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.
COMPOUND, RESIN PRECURSOR, CURED OBJECT, OPTICAL ELEMENT, OPTICAL SYSTEM, INTERCHANGEABLE CAMERA LENS, OPTICAL DEVICE, CEMENTED LENS, AND METHOD FOR MANUFACTURING CEMENTED LENS
A compound represented by Formula (1) given below. (In the formula, R.sup.1 represents a hydrogen atom or a methyl group, and X represents a C.sub.2 to 6 alkylene group, a C.sub.4 to 6 alkylene group containing an oxygen atom and/or a sulfur atom, or a C.sub.3 to 6 alkylene group in which at least one hydrogen is replaced with an acryloxy group or a methacryloxy group.)
COMPOUND, RESIN PRECURSOR, CURED OBJECT, OPTICAL ELEMENT, OPTICAL SYSTEM, INTERCHANGEABLE CAMERA LENS, OPTICAL DEVICE, CEMENTED LENS, AND METHOD FOR MANUFACTURING CEMENTED LENS
A compound represented by Formula (1) given below. (In the formula, R.sup.1 represents a hydrogen atom or a methyl group, and X represents a C.sub.2 to 6 alkylene group, a C.sub.4 to 6 alkylene group containing an oxygen atom and/or a sulfur atom, or a C.sub.3 to 6 alkylene group in which at least one hydrogen is replaced with an acryloxy group or a methacryloxy group.)
ORGANIC COMPOUNDS, MIXTURES, AND USES THEREOF IN ORGANIC ELETRONIC DEVICES
Provided are organic compounds including a structure of formula (I). Also provided are mixtures containing the organic compounds. Further provided are organic electronic devices containing the organic compounds or mixtures.
COMPOUND, MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE COMPOUND
Specific compounds represented by formula (1), a material for an organic electroluminescence device comprising said specific compound, an organic electroluminescence device comprising said specific compound, an electronic equipment comprising said organic electroluminescence device and the use of said compounds in an organic electroluminescence device.
##STR00001##
COMPOUND, MATERIAL FOR AN ORGANIC ELECTROLUMINESCENCE DEVICE AND AN ORGANIC ELECTROLUMINESCENCE DEVICE COMPRISING THE COMPOUND
Specific compounds represented by formula (1), a material for an organic electroluminescence device comprising said specific compound, an organic electroluminescence device comprising said specific compound, an electronic equipment comprising said organic electroluminescence device and the use of said compounds in an organic electroluminescence device.
##STR00001##
ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE
An organic compound represented by formula [1]:
##STR00001##
where R.sub.1 to R.sub.14 are each independently selected from the group consisting of a hydrogen atom and substituents, wherein at least one of R.sub.1 to R.sub.4 and R.sub.8 to R.sub.11 is an amino group or an amino group-containing group, and X is oxygen, sulfur, selenium, tellurium, or a CR.sub.15R.sub.16 group, wherein R.sub.15 and R.sub.16 are each independently selected from the group consisting of a hydrogen atom and substituents.
ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE
An organic compound represented by formula [1]:
##STR00001##
where R.sub.1 to R.sub.14 are each independently selected from the group consisting of a hydrogen atom and substituents, wherein at least one of R.sub.1 to R.sub.4 and R.sub.8 to R.sub.11 is an amino group or an amino group-containing group, and X is oxygen, sulfur, selenium, tellurium, or a CR.sub.15R.sub.16 group, wherein R.sub.15 and R.sub.16 are each independently selected from the group consisting of a hydrogen atom and substituents.
Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibitor and antitumor agents
The present invention provides a compound of Formula III, and salts thereof, and a pharmaceutical composition comprising a compound of Formula III: ##STR00001##
wherein R.sub.1 is selected from the group consisting of: ##STR00002##
wherein
R.sub.2 is H or an alkyl group having from one to ten carbon atoms; R.sub.3 is H or an alkyl group having from one to ten carbon atoms; and R.sub.4 is H or an alkyl group having from one to ten carbon atoms. Methods of treating a patient with cancer with these compounds are also provided.
Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibitor and antitumor agents
The present invention provides a compound of Formula III, and salts thereof, and a pharmaceutical composition comprising a compound of Formula III: ##STR00001##
wherein R.sub.1 is selected from the group consisting of: ##STR00002##
wherein
R.sub.2 is H or an alkyl group having from one to ten carbon atoms; R.sub.3 is H or an alkyl group having from one to ten carbon atoms; and R.sub.4 is H or an alkyl group having from one to ten carbon atoms. Methods of treating a patient with cancer with these compounds are also provided.