Patent classifications
C07D489/00
Process for the formation of hydrocodone bitatrate
There is provided a novel process for the preparation of a hydrocodone salt. In particular, there is provided a novel process for the preparation of a free-flowing slurry of a hydrocodone salt, for example, a free-flowing slurry of hydrocodone bitartrate hemipentahydrate.
8-carboxamido-2,6-methano-3-benzazocines
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is CH.sub.2OH, CH.sub.2NH.sub.2, NHSO.sub.2CH.sub.3, ##STR00001##
and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ##STR00002##
8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
8-carboxamido-2,6-methano-3-benzazocines
8-Substituted-2,6-methano-3-benzazocines of general structure I in which A is CH.sub.2OH, CH.sub.2NH.sub.2, NHSO.sub.2CH.sub.3, ##STR00001##
and Y is O, S or NOH are useful as analgesics, anti-diarrheal agents, anticonvulsants, antitussives and anti-addiction medications. ##STR00002##
8-Carboxamides, thiocarboxamides, hydroxyamidines and formamides are preferred.
METHODS FOR THE CHEMICAL SYNTHESIS OF PYRROLE-LINKED BIVALENT COMPOUNDS, AND COMPOSITIONS THEREOF
The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.
METHODS FOR THE CHEMICAL SYNTHESIS OF PYRROLE-LINKED BIVALENT COMPOUNDS, AND COMPOSITIONS THEREOF
The present invention in various aspects relates to the synthesis of pyrrole-linked bivalent compounds, including but not limited to norBNI, as well as pharmaceutical compositions comprising the same.
Crystal forms of (R)-N-methylnaltrexone bromide and uses thereof
The present invention provides a new forms of (R)-N-methylnaltrexone, and compositions thereof, useful as a peripheral mu opioid receptor antagonist.
Morphan And Morphinan Analogues, And Methods Of Use
The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
Morphan And Morphinan Analogues, And Methods Of Use
The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.
6-ACETYLMORPHINE ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.
6-ACETYLMORPHINE ANALOGS, AND METHODS FOR THEIR SYNTHESIS AND USE
The present invention relates to novel 6-acetylmorphine analogs, and methods for their synthesis and use. Such analogs are designed to provide a convenient linkage chemistry for coupling under mild conditions to a suitable group on a target protein, polypeptide, solid phase or detectable label.