The invention relates to compounds of general formula (I) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, m and n are defined as defined herein, and pharmaceutically acceptable salts, hydrates, or solvates thereof, for usealone or in combination with one or more other pharmaceutically active compoundsin therapy, as JAK kinase and protein tyrosine kinase inhibitors for preventing, treating or ameliorating diseases and complications thereof, including, for example, psoriasis, atopic dermatitis, rosacea, lupus, multiple sclerosis, rheumatoid arthritis, Type I diabetes, asthma, cancer, autoimmune thyroid disorders, ulcerative colitis, Crohn's disease, Alzheimer's disease, leukaemia, eye diseases such as diabetic retinopathy and macular degeneration as well as other autoimmune diseases and indications where immuno-suppression would be desirable for example in organ transplantation. ##STR00001##

The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: ##STR00001##
and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R.sup.1a, A, B.sup.1, B.sup.2, G, X.sup.1, Y.sup.1, Y.sup.2, and Y.sup.3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

The present invention relates to a compound having the structure of Formula I as inhibitor of WNT signal transduction pathways, as well as a composition comprising the compound. Further, the present invention relates to the use of the compound and the method of inhibiting the WNT signal transduction pathways. ##STR00001##

This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Disclosed is an analgesic composition including an opioid analgesic and a therapeutically effective amount of P7C3, and the present analgesic composition may treat acute and facilitated pain very effectively, and has a significantly high synergistic effect compared to the effect by administration of individual drugs.