The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

An iridium (III) complex compound with cyclic quinoxaline-fused dibenzosuberene ligand is shown in General Formula (1),

##STR00001## wherein m is 1 or 2, n is 1 or 2, and m+n is 3; A is a bridging atom represented by General Formula (2) or General Formula (3),

##STR00002## wherein R.sub.1 is a hydrogen atom, alkyl or tert-butyl group, R.sub.2 to R.sub.14 are independently selected from the group consisting of hydrogen atom, halogen atom, cyano group, alkyl group, cycloalkyl group, aryl group, alkoxy group, amino group, thioalkyl group, silyl group and alkenyl group.

An iridium (III) complex compound with cyclic quinoxaline-fused dibenzosuberene ligand is shown in General Formula (1),

##STR00001## wherein m is 1 or 2, n is 1 or 2, and m+n is 3; A is a bridging atom represented by General Formula (2) or General Formula (3),

##STR00002## wherein R.sub.1 is a hydrogen atom, alkyl or tert-butyl group, R.sub.2 to R.sub.14 are independently selected from the group consisting of hydrogen atom, halogen atom, cyano group, alkyl group, cycloalkyl group, aryl group, alkoxy group, amino group, thioalkyl group, silyl group and alkenyl group.

The present invention utilizes a high-speed intensive mixer in fluidizing type solid phase neutralization reactor to blend solid state alkali hydroxide with any humic acid sources. The final product is a dry humic acid salt. The purpose of this innovative method is to eliminate a series of complicated unit operations commonly employed by the traditional process. These removed steps may include dissolving caustic soda, mixing in a paste like formation, extrusion, granulation, drying, and grinding, etc. The new invention contributes to a simplified flowsheet, resulting in sharply reduced equipment investment, the required plant space, and labor and energy costs. All these factors coupled with increased productivity will drastically lower the overall production cost. Also the reduction of dust pollution will greatly minimize the impact in environmental protection and safety issues.

The present invention utilizes a high-speed intensive mixer in fluidizing type solid phase neutralization reactor to blend solid state alkali hydroxide with any humic acid sources. The final product is a dry humic acid salt. The purpose of this innovative method is to eliminate a series of complicated unit operations commonly employed by the traditional process. These removed steps may include dissolving caustic soda, mixing in a paste like formation, extrusion, granulation, drying, and grinding, etc. The new invention contributes to a simplified flowsheet, resulting in sharply reduced equipment investment, the required plant space, and labor and energy costs. All these factors coupled with increased productivity will drastically lower the overall production cost. Also the reduction of dust pollution will greatly minimize the impact in environmental protection and safety issues.

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

The present invention relates to compounds useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.

Compounds of formula I and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.

##STR00001##