Provided herein are compounds useful as imaging agents. Exemplary compounds provided herein are useful as myeloperoxidase imaging agents using magnetic resonance or nuclear imaging techniques. Methods for preparing the compounds provided herein and diagnostic methods using the compounds are also provided.

The present disclosure relates to an yttrium/lanthanide metal precursor compound, a precursor composition for depositing an yttrium/lanthanide metal-containing film including the yttrium/lanthanide metal precursor compound, and a method of depositing the yttrium/lanthanide metal-containing film using the precursor composition.

A chelate and associated security feature including a lanthanide metal and a ligand of formula (1), formula (2), or formula (3), ##STR00001##
where each of R.sub.1-R.sub.7 in formula (1) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, alkyl, aryl, phenyl, OPh, and heteroaromatic, where each of R.sub.1-R.sub.5 in formula (2) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, NMe.sub.2, CN, alkyl, aryl, phenyl, OPh, and heteroaromatic, and where R.sub.6 in formula (2) is selected from the group consisting of H, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, NMe.sub.2, CN, alkyl, aryl, phenyl, OPh, and heteroaromatic, and where each of R.sub.1-R.sub.5 in formula (3) is independently selected from the group consisting of H, OH, NH.sub.2, Cl, F, OMe, OAr, OCF.sub.3, CF.sub.3, alkyl, aryl, phenyl, OPh, and heteroaromatic.

In a compound of the present invention, in a macroscopic view of a chemical structure thereof, a chelating moiety is located at the center of the structure, an atomic group containing an albumin binding moiety binds to one side of the chelating moiety, and an atomic group containing a target molecule binding moiety binds to the other side of the chelating moiety. The chelating moiety is also preferably DOTA or a derivative thereof. The target molecule binding moiety preferably has a structure to bind to a target molecule expressed in a cancer tissue. The present invention also provides a radioactive labeled compound in which the compound is coordinated to a radioactive metal ion.

The present invention relates to novel luminescent lanthanide chelate reporters which are formed from two to three separate lanthanide chelate moieties covalently conjugated to each other to act as an unique labelling reactant, and which can be attached to a biospecific reactant and used in various assays.

Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I):

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 each independently represent an alkyl group which may have a substituent.

Disclosed is a rare earth complex having a rare earth ion and a phosphine oxide ligand that is coordinated with the rare earth ion and is represented by the following formula (I):

##STR00001## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, and R.sup.6 each independently represent an alkyl group which may have a substituent.

Provided is a thin-film forming raw material, which is used in an atomic layer deposition method, including a compound represented, by the following formula (1) :

##STR00001##

where R.sup.1 and R.sup.2 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, L represents a group represented by the following formula (L-1) or (L-2), and M represents an indium atom or a gallium atom;

##STR00002##

where R.sup.11 and R.sup.12 each independently represent a hydrogen atom, a fluorine atom, an alkyl group having 1 to 5 carbon atoms, or an alkoxy group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1);

##STR00003##

where R.sup.21 to R.sup.23 each independently represent a hydrogen atom, a fluorine atom, or an alkyl group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1), provided that R.sup.21 and R.sup.22 represent different groups.

Provided is a thin-film forming raw material, which is used in an atomic layer deposition method, including a compound represented, by the following formula (1) :

##STR00001##

where R.sup.1 and R.sup.2 each independently represent a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, L represents a group represented by the following formula (L-1) or (L-2), and M represents an indium atom or a gallium atom;

##STR00002##

where R.sup.11 and R.sup.12 each independently represent a hydrogen atom, a fluorine atom, an alkyl group having 1 to 5 carbon atoms, or an alkoxy group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1);

##STR00003##

where R.sup.21 to R.sup.23 each independently represent a hydrogen atom, a fluorine atom, or an alkyl group having 1 to 5 carbon atoms, and * represents a bonding position with M in the formula (1), provided that R.sup.21 and R.sup.22 represent different groups.

The present technology relates to luminescent lanthanide complexes comprising a chelating agent, formed of a macrocycle or ligand, complexing a lanthanide ion Ln.sup.3+ selected from terbium and dysprosium, the chelating agent comprising at least one group of the structure (B) below; and a process for detecting a biomolecule using said lanthanide complex comprising coupling a luminescent lanthanide complex of the present technology having a reactive group with said biomolecule. ##STR00001##