A chemoselective and reactive Mn(CF.sub.3-PDP) catalyst system that enables for the first time the strategic advantages of late-stage aliphatic CH hydroxylation to be leveraged in aromatic compounds. This discovery will benefit small molecule therapeutics by enabling the rapid diversification of aromatic drugs and natural products and identification of their metabolites.

A method suitable for use in investigating synthesis conditions for metal-organic frameworks may include: identifying synthesis conditions that includes a first solvent system by which a metal-organic framework is successfully synthesized; and synthesizing the metal-organic framework under substantially the same synthesis conditions but with a second solvent system (or a comparable solvent system) having a difference (R.sub.a) between Hansen solubility parameters of 5 MPa.sup.0.5 or less as compared to the first solvent system.

Systems and methods for automatically generating a set of meta-parameters used to train invariant-based anomaly detectors are provided. Data is transformed into a first set of time series data and a second set of time series data. A fitness threshold search is performed on the first set of time series data to automatically generate a fitness threshold, and a time resolution search is performed on the set of second time series data to automatically generate a time resolution. A set of meta-parameters including the fitness threshold and the time resolution are sent to one or more user devices across a network to govern the training of an invariant-based anomaly detector.

Complex compounds of transition metals according to formula (1) wherein the M(CO).sub.3.sup.+ tricarbonyl-metal core forms a complex with the cyclopentadienyl anion linked to heterocyclic moieties of the benzothiazole, benzimidazole and benzoxazole families. The compounds exhibit high blood-brain barrier permeability and can be used in the diagnosis and/or treatment of diseases of the Central Nervous System.

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Methods are provided for synthesizing metal organic framework compositions in an aqueous environment and/or in a mixed alcohol/water solvent. The methods can allow for formation of MOF-274 metal organic framework compositions, such as EMM-67 (a mixed metal MOF-274 metal organic framework composition). More generally, the methods can allow for formation of MOF structures that include disalicylate linkers in an aqueous environment and/or in a mixed alcohol/water solvent.

The present disclosure relates to a process for preparing a transition metal-Schiff base imine ligand complex. The process involves direct chelation of a Schiff base imine ligand by adding a transition metal halide in a halogenated fluid medium at a temperature in the range of 20 C. to 40 C. The process employs less hazardous reagents and mild reaction conditions to obtain the complex. The complex is efficient to be used as a catalyst for the production of disentangled ultra-high molecular weight polyethylene.

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Organometallic compounds useful in chemical phase deposition processes such as atomic layer deposition (ALD) and chemical vapor deposition (CVD). The compounds correspond in structure to Formula 1:

[(R.sup.1R.sup.2R.sup.3(A)).sub.x-M(CO).sub.y].sub.z wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of H, a lower alkyl group and a phenyl group optionally substituted with at least one independently selected lower alkyl group, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 must be other than H; M is selected from the group consisting of the cobalt group metals, the iron group metals, the manganese group metals, and the chromium group metals; A is selected from the group consisting of Si, Ge, and Sn; and wherein: x=1, y=4, and z=1 when M is selected from the group consisting of a cobalt group metal, x=1, y=5, and z=1 when M is selected from the group consisting of a manganese group metal, x=2, y=4, and z=1 when M is selected from the group consisting of a chromium group metal, and x=2, y=4, and z=1 or, alternatively, x=1, y=4, and z=2 when M is selected from the group consisting of an iron group metal.
Methods of deposition are also provided which involve the reaction of at least one of the compounds of the invention, in the presence of co-reagents, to generate metal carbonyl hydrides which can decompose cleanly and thermally to form substantially pure metal films, metal oxide films, metal nitride films, metal phosphide films, metal boride films or metal sulphide films. Methods of selective deposition, such that metal or metal-containing films are deposited selectively on certain substrates and not on other substrate materials.

Organometallic compounds useful in chemical phase deposition processes such as atomic layer deposition (ALD) and chemical vapor deposition (CVD). The compounds correspond in structure to Formula 1:

[(R.sup.1R.sup.2R.sup.3(A)).sub.x-M(CO).sub.y].sub.z wherein R.sup.1, R.sup.2 and R.sup.3 are independently selected from the group consisting of H, a lower alkyl group and a phenyl group optionally substituted with at least one independently selected lower alkyl group, with the proviso that at least one of R.sup.1, R.sup.2 and R.sup.3 must be other than H; M is selected from the group consisting of the cobalt group metals, the iron group metals, the manganese group metals, and the chromium group metals; A is selected from the group consisting of Si, Ge, and Sn; and wherein: x=1, y=4, and z=1 when M is selected from the group consisting of a cobalt group metal, x=1, y=5, and z=1 when M is selected from the group consisting of a manganese group metal, x=2, y=4, and z=1 when M is selected from the group consisting of a chromium group metal, and x=2, y=4, and z=1 or, alternatively, x=1, y=4, and z=2 when M is selected from the group consisting of an iron group metal.
Methods of deposition are also provided which involve the reaction of at least one of the compounds of the invention, in the presence of co-reagents, to generate metal carbonyl hydrides which can decompose cleanly and thermally to form substantially pure metal films, metal oxide films, metal nitride films, metal phosphide films, metal boride films or metal sulphide films. Methods of selective deposition, such that metal or metal-containing films are deposited selectively on certain substrates and not on other substrate materials.

The disclosure relates to tagged nucleoside compounds comprising a nucleotide polyphosphate covalently attached to a tag, wherein the compound is a polymerase substrate and the polymer moiety is capable of entering a nanopore linked to the polymerase and thereby altering the flow of ions through the nanopore. The disclosure also provides methods for preparing the tagged nucleoside compounds and for their use as tags in nanopore-based nucleic acid detection and sequencing.

Disclosed herein are novel amine-functionalized porphyrin compounds, as wells as pharmaceutically acceptable salts or esters thereof. The disclosed compounds can be used to impart antioxidant, anti-inflammatory, anti-microbial, and/or cell-adhesion specificity to a surface or material in need thereof, such as a surface of an indwelling medical implant, or a marine surface.