Disclosed herein are compounds having a structure according to Formula I and optionally Formula IV.

##STR00001##

The compounds may be radiolabeled compounds useful for diagnosis and/or imaging fungal infections. In such embodiments, at least one substituent is a radionuclide, such as .sup.18F. Also disclosed are precursor compounds according to Formula I and/or IV that are useful for making the radiolabeled compounds. In such embodiments, the precursor compound comprises at least one leaving group suitable for introducing a radionuclide, such as .sup.18F, at a desired position.

Also disclosed are methods for making and using the compounds, including embodiments of a method for imaging and/or diagnosing a fungal infection in a subject.

The present disclosure provides for improved binder compositions comprising an amine component, as well as methods for manufacturing articles and collections of matter comprising the disclosed binder compositions.

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: ##STR00001##
The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: ##STR00001##
The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

The present invention relates to sulphated disaccharides of formula (I) for use in the treatment of neuropathic pain. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I) and at least one pharmaceutically acceptable excipient for use in the treatment of neuropathic pain. The compounds of formula (I) were effective in several experimental models of neuropathic pain for which reason these compounds can be used effectively for the treatment of different types of neuropathic pain and the clinical manifestations thereof, for example, mechanical allodynia or cold allodynia.

The present invention relates to sulphated disaccharides of formula (I) for use in the treatment of neuropathic pain. The present invention also relates to a pharmaceutical composition comprising the compound of formula (I) and at least one pharmaceutically acceptable excipient for use in the treatment of neuropathic pain. The compounds of formula (I) were effective in several experimental models of neuropathic pain for which reason these compounds can be used effectively for the treatment of different types of neuropathic pain and the clinical manifestations thereof, for example, mechanical allodynia or cold allodynia.

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV:

##STR00001##

The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV:

##STR00001##

The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

An object of the invention is to provide a method of uniformly and efficiently producing a saccharide having a sulfate group and/or a phosphate group in the molecule, or a compound containing the saccharide. [Solution] The present invention provides a method of producing a saccharide having a sulfate group and/or a phosphate group. The method comprises (a) a step of preparing a first saccharide having a non-protected sulfate group and/or a non-protected phosphate group and a second saccharide having a non-protected sulfate group and/or a non-protected phosphate group and (b) a step of condensing the first saccharide and the second saccharide prepared in the step (a) with each other.

An object of the invention is to provide a method of uniformly and efficiently producing a saccharide having a sulfate group and/or a phosphate group in the molecule, or a compound containing the saccharide. [Solution] The present invention provides a method of producing a saccharide having a sulfate group and/or a phosphate group. The method comprises (a) a step of preparing a first saccharide having a non-protected sulfate group and/or a non-protected phosphate group and a second saccharide having a non-protected sulfate group and/or a non-protected phosphate group and (b) a step of condensing the first saccharide and the second saccharide prepared in the step (a) with each other.