A use of one or more lipid compounds in the delivery of nucleic acids, and a lipid nucleic acid mixture, pharmaceutical composition or kit comprising the lipid compounds and nucleic acids. The lipid compounds can promote the absorption, particularly oral absorption, of nucleic acids, and promote entry of nucleic acids into target sites in a subject in need thereof.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

The present invention relates to digoxin and digitoxin derivatives that are selective inhibitors of the 2 isoform of Na,K-ATPase, and that reduce intra-ocular pressure. The invention further relates to uses of these derivatives for treating disorders associated with elevated intraocular pressure, such as glaucomas, and/or as cardiotonic agents.

The technology disclosed herein concerns de-hydroxylated cardiac steroid of formula (I) and uses thereof in medicine.

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The technology disclosed herein concerns de-hydroxylated cardiac steroid of formula (I) and uses thereof in medicine.

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Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.

Chemical entities that are novel compounds, pharmaceutical compositions and methods of treatment of cancer are described.