Patent classifications
C07J75/00
PROCESS FOR THE PREPARATION OF 3beta-HYDROXY-17-(1H-BENZIMIDAZOL-1-YL)ANDROSTA-5,16-DIENE
A process for the synthesis of β-hydroxy 3-17-(1H-benzimidazol-1-yl)androsta-5,16-diene is described, a compound also known as Galeterone and used in the treatment of prostate cancer, having the formula 6).
##STR00001##
Process for the Preparation of Obeticholic Acid and Intermediates Used In the Process Thereof
The present invention relates to an improved process for the preparation of Obeticholic acid and intermediates used in the process thereof. The invention also relates to a solid form of tertiary butylamine salt of Obeticholic acid and tertiary butylamine salt of Obeticholic acid in the solvate form.
Process for the Preparation of Obeticholic Acid and Intermediates Used In the Process Thereof
The present invention relates to an improved process for the preparation of Obeticholic acid and intermediates used in the process thereof. The invention also relates to a solid form of tertiary butylamine salt of Obeticholic acid and tertiary butylamine salt of Obeticholic acid in the solvate form.
NOVEL FORM OF BARDOXOLONE METHYL
The present disclosure relates to a formic acid solvate of bardoxolone methyl and to a process for its preparation. The present disclosure also relates to pharmaceutical compositions comprising the formic acid solvate of bardoxolone methyl and to its use in a method for treating a disease.
NOVEL FORM OF BARDOXOLONE METHYL
The present disclosure relates to a formic acid solvate of bardoxolone methyl and to a process for its preparation. The present disclosure also relates to pharmaceutical compositions comprising the formic acid solvate of bardoxolone methyl and to its use in a method for treating a disease.
METHODS FOR ASSEMBLY OF TETRACYCLIC COMPOUNDS BY STEREOSELECTIVE C9-C10 BOND FORMATION
The present disclosure relates to stereodefined polycyclic (e.g., tetracyclic) compounds that contain quaternary centers at one or multiple ring fusions, synthetic methods for preparing such compounds, and methods of using such compounds to treat a disease, such as a brain tumor and, particularly, a glioma.
Preparation of bile acids and intermediates thereof
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
Preparation of bile acids and intermediates thereof
Synthetic methods for preparing deoxycholic acid and intermediates thereof are provided.
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Compounds are provided according to Formula (I):
##STR00001##
and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v):
##STR00002##
and wherein L.sup.1, L.sup.2, L.sup.3, X.sup.1, X.sup.2, Y, R.sup.Z4, R.sup.Z5, R.sup.Z6, n, R.sup.1, R.sup.2, R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b, R.sup.6a, R.sup.6b, R.sup.7a, R.sup.7b, R.sup.11a, R.sup.11b, R.sup.14, R.sup.17, R.sup.19, R.sup.20, R.sup.23a, R.sup.23b, and R.sup.24 are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.
NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF
Compounds are provided according to Formula (I):
##STR00001##
and pharmaceutically acceptable salts thereof, wherein Z is a group of the formula (i), (ii), (iii), (iv), or (v):
##STR00002##
and wherein L.sup.1, L.sup.2, L.sup.3, X.sup.1, X.sup.2, Y, R.sup.Z4, R.sup.Z5, R.sup.Z6, n, R.sup.1, R.sup.2, R.sup.3a, R.sup.3b, R.sup.4a, R.sup.4b, R.sup.6a, R.sup.6b, R.sup.7a, R.sup.7b, R.sup.11a, R.sup.11b, R.sup.14, R.sup.17, R.sup.19, R.sup.20, R.sup.23a, R.sup.23b, and R.sup.24 are as defined herein, and pharmaceutical compositions thereof. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of CNS-related conditions in mammals.