The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system. page.

Vancomycin conjugates of Formula I, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complexes thereof is described in the present disclosure. Further, the present disclosure relates to pharmaceutical compositions comprising vancomycin conjugates, its stereoisomers, prodrugs, pharmaceutically 10 acceptable salts, metal coordination complex thereof with one or more other pharmaceutical compositions or an antibiotic. The present disclosure also describes a process of preparing said conjugates, its stereoisomers, prodrugs, pharmaceutically acceptable salts, and metal coordination complex thereof, and pharmaceutical compositions as described above. Furthermore, the present disclosure describes 15 compositions and methods of treating conditions and diseases that are mediated by bacteria. ##STR00001##

Disclosed is a chromatographic method for separating a mixture of compounds having ionizable groups using a mobile phase comprising (a) a first mobile phase component comprising an aqueous buffer system and an organic solvent mixture miscible with water, and (b) a second mobile phase component comprising an aqueous buffer system and an organic solvent mixture miscible with water, wherein the buffer system and the solvent mixture in the first mobile phase component are different from the buffer system and the solvent mixture in the second mobile phase component and the ratio of the first mobile phase component to the second mobile phase component is varied during the separation. The method can be used for the separation of vancomycin and its degradation products.

Disclosed herein are compositions for assessing peptidoglycan biosynthesis in bacteria, for identifying bacteria, and for screening for bacterial cell wall-acting and/or cell wall-disrupting agents via modified D-amino acids and methods of use thereof. Also disclosed are live bacteria having one or more modified D-amino acids as described herein incorporated into peptidoglycan of a bacterial cell wall.

The present disclosure relates to a phage-based matrix for inducing stem cell differentiation and a method for preparing the same. More specifically, the present disclosure relates to a composition for inducing differentiation of stem cells, which includes a phage-based matrix in which a gradient of stiffness is controlled by crosslinking a recombinant phage with a polymer, and a method for preparing a phage-based matrix for stem cell differentiation. According to the present invention, the method of the present disclosure provides a physical and mechanical niche environment created by the formation of a nanofibrous structure of the phage whose stiffness is controlled, thereby promoting the differentiation of stem cells into target cells. Therefore, it can be applied to a tissue matrix platform as a variety of conventional tissue engineering materials.

The present disclosure relates to a phage-based matrix for inducing stem cell differentiation and a method for preparing the same. More specifically, the present disclosure relates to a composition for inducing differentiation of stem cells, which includes a phage-based matrix in which a gradient of stiffness is controlled by crosslinking a recombinant phage with a polymer, and a method for preparing a phage-based matrix for stem cell differentiation. According to the present invention, the method of the present disclosure provides a physical and mechanical niche environment created by the formation of a nanofibrous structure of the phage whose stiffness is controlled, thereby promoting the differentiation of stem cells into target cells. Therefore, it can be applied to a tissue matrix platform as a variety of conventional tissue engineering materials.

The present application provides stable peptide-based anti-gp41 antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing anti-gp41 antibody capture agents using iterative on-bead in situ click chemistry.

The present application provides stable peptide-based anti-gp41 antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing anti-gp41 antibody capture agents using iterative on-bead in situ click chemistry.

The present invention provides a peptide containing 8 or more consecutive amino acid residues in an amino acid sequence of any of SEQ ID NOS: 1 to 11 and consisting of 11 or less amino acid residues.

Provided are compounds having the Formula I or II: ##STR00001##
and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and their use in the treatment of cancers.