The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

Disclosed herein are processes for separating liquefied grains prior to a fermentation. The described processes enable separation of insoluble biomass solids from soluble carbohydrates to yield at least one biomass solids fraction and at least one carbohydrates-rich fraction. The process involves an initial dilution step where liquefied grains are combined with either water or a recycled soluble matter stream, the latter comprising an aqueous solution of residual carbohydrates recovered from a first bioprocessing stage. The diluted liquid mash undergoes a first fractionation stage involving mechanical processing, yielding two distinct streams: a first retentate stream containing insoluble biomass solids and residual carbohydrates, and a permeate stream containing dissolved carbohydrates. The first retentate stream is then mechanically processed in a first bioprocessing stage, resulting in two outputs: a processed first retentate stream containing the insoluble biomass solids, and the recycled soluble matter stream containing residual carbohydrates. The process culminates in the collection of dissolved carbohydrates and insoluble biomass solids, which constitute the carbohydrates-rich fraction and biomass solids fraction, respectively. These processes provide efficient separation of grain components to yield extremely clean fermentation medium for ethanol and useful biomass solid products untainted by fermentation processes.

The present disclosure provides a novel and biodegradable thermoplastic starch composition and a preparation method thereof. Compared to conventional thermoplastic starch materials, the thermoplastic starch composition of the present disclosure shows enhanced mechanical strength, improved stability and resistance to retrogradation, and is able to maintain their biodegradability with no need for blending with fossil-based plastics.

The present disclosure provides a novel and biodegradable thermoplastic starch composition and a preparation method thereof. Compared to conventional thermoplastic starch materials, the thermoplastic starch composition of the present disclosure shows enhanced mechanical strength, improved stability and resistance to retrogradation, and is able to maintain their biodegradability with no need for blending with fossil-based plastics.