This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

This invention relates to anti-microbial active particles, compositions and uses thereof for inhibiting bacterial growth on surfaces or devices. This invention further discloses methods of making such anti-microbial active particles.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C═O)OR′, wherein R′ is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(C═O)OR′, wherein R′ is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

The present invention belongs to the technical field of composite materials, and disclosed are a xylan-based double network nanocomposite hydrogel and the preparation and application thereof. The method includes: (1) adding a graphite oxide powder into deionized water, and ultrasonically dispersing to obtain a GO water dispersion; (2) adding xylan into deionized water, heating and stiffing to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO water dispersion, stiffing and dispersing uniformly under an ice-bath condition, adding an initiator, a cross-linking agent and an accelerator, and stiffing to mix well so as to obtain a mixed solution; (4) subjecting the mixed solution of step (3) to a drying reaction, to obtain the xylan based double network nanocomposite hydrogel. The composite hydrogel obtained in the present invention has high mechanical properties, is biodegradable and has good biocompatibility. The present invention is applicable in the field of biomedicine, such as tissue engineering, drug sustained-release, cell culture scaffold and cartilage tissue, etc.

A water-based barrier coating composition suitable for use as a barrier coating is disclosed which includes an aqueous polymer composition obtainable by free radical (co)polymerizing an ethylenically unsaturated monomer blend having an optionally substituted styrene, at least one C1-C4-alkyl (meth)acrylate, other ethylenically unsaturated copolymerizable monomers, degraded starch polyvinyl alcohol (PVA), a plasticizer; a composition having C16-C18 alkenyl ketene dimer, optionally as a mixture with rosin, of a gelling agent; and optionally a filler.

A water-based barrier coating composition suitable for use as a barrier coating is disclosed which includes an aqueous polymer composition obtainable by free radical (co)polymerizing an ethylenically unsaturated monomer blend having an optionally substituted styrene, at least one C1-C4-alkyl (meth)acrylate, other ethylenically unsaturated copolymerizable monomers, degraded starch polyvinyl alcohol (PVA), a plasticizer; a composition having C16-C18 alkenyl ketene dimer, optionally as a mixture with rosin, of a gelling agent; and optionally a filler.

A water-based barrier coating composition suitable for use as a barrier coating is disclosed which includes an aqueous polymer composition obtainable by free radical (co)polymerizing an ethylenically unsaturated monomer blend having an optionally substituted styrene, at least one C1-C4-alkyl (meth)acrylate, other ethylenically unsaturated copolymerizable monomers, degraded starch polyvinyl alcohol (PVA), a plasticizer; a composition having C16-C18 alkenyl ketene dimer, optionally as a mixture with rosin, of a gelling agent; and optionally a filler.

The invention relates to a drug delivery device adapted for carrying and delivering both hydrophilic and lipophilic drug molecules. The drug delivery device includes a porous body for adsorption of drug molecules, the body including a plurality of microspheres, and a hydrogel forming cross-links connecting the plurality of microspheres.

The invention relates to a drug delivery device adapted for carrying and delivering both hydrophilic and lipophilic drug molecules. The drug delivery device includes a porous body for adsorption of drug molecules, the body including a plurality of microspheres, and a hydrogel forming cross-links connecting the plurality of microspheres.