Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(CO)OR, wherein R is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(CO)OR, wherein R is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

This invention includes a wettable biomedical device containing a high molecular weight hydrophilic polymer and a hydroxyl-functionalized silicone-containing monomer.

The present invention relates to an interpenetrating polymer network (IPN) material comprising a copolymer of vinylamine-vinylformamide, and a homo-polymer or a copolymer of at least one monomer selected from acrylamide or derivatives thereof, acrylic acid or derivatives thereof, or a mixture thereof forming the IPN material together with the copolymer of vinylamine-vinyl-formamide. The present invention further relates to a process for producing the IPN material, and to use of the IPN material in paper industry.

The present invention relates to an interpenetrating polymer network (IPN) material comprising a copolymer of vinylamine-vinylformamide, and a homo-polymer or a copolymer of at least one monomer selected from acrylamide or derivatives thereof, acrylic acid or derivatives thereof, or a mixture thereof forming the IPN material together with the copolymer of vinylamine-vinyl-formamide. The present invention further relates to a process for producing the IPN material, and to use of the IPN material in paper industry.

The present invention relates to an interpenetrating polymer network (IPN) material comprising a copolymer of vinylamine-vinylformamide, and a homo-polymer or a copolymer of at least one monomer selected from acrylamide or derivatives thereof, acrylic acid or derivatives thereof, or a mixture thereof forming the IPN material together with the copolymer of vinylamine-vinyl-formamide. The present invention further relates to a process for producing the IPN material, and to use of the IPN material in paper industry.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(CO)OR, wherein R is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

Methods for preparing water soluble, non-peptidic polymers carrying carboxyl functional groups, particularly carboxylic acid functionalized poly(ethylene glycol) (PEG) polymers are disclosed, as are the products of these methods. In general, an ester reagent R(CO)OR, wherein R is a tertiary group and R comprises a functional group X, is reacted with a water soluble, non-peptidic polymer POLY-Y, where Y is a functional group which reacts with X to form a covalent bond, to form a tertiary ester of the polymer, which is then treated with a strong base in aqueous solution, to form a carboxylate salt of the polymer. Typically, this carboxylate salt is then treated with an inorganic acid in aqueous solution, to convert the carboxylate salt to a carboxylic acid, thereby forming a carboxylic acid functionalized polymer.

The present invention concerns a process for preparing a polymer comprising at least one gel polymerization step (E) in which the following are contacted: ethylenically unsaturated water-soluble monomers, the same or different; a source of free radicals adapted to the polymerization of the said monomers, typically a redox system; and a radical polymerization control agent, preferably comprising a thiocarbonylthio S(CS) group;
with a concentration of monomers in the reaction medium of step (E) sufficiently high to cause gelling of the medium if polymerization was conducted without the control agent.