A photoresponsive polymer includes a structural unit represented by the following general formula (1), the photoresponsive polymer being fluidized by light irradiation, and reversibly non-fluidized:

[Chemical formula 1]

R.sub.1—Z.sub.1═Z.sub.2—R.sub.2  General formula (1) in the formula, Z.sub.1 and Z.sub.2 each represent CH or N, and Z.sub.1≠Z.sub.2, R.sub.1 represents an aromatic hydrocarbon group having a substituent R.sub.a selected from the group consisting of an alkyl group, an alkoxy group, and a halogen atom at each of two ortho positions with respect to Z.sub.1, R.sub.2 represents an aromatic heterocyclic group with or without a substituent, and at least one of the R.sub.1 and the R.sub.2 is bonded to a group containing a structure derived from a polymerizable group.

A method of preparing PNVCL block polymers as the substrate for thermo-sensitive cultureware is provided. A hydrophobic polymer of poly n-butyl mathacrylate (PBMA) is obtained by atom transfer radical polymerization (ATRP) with typical haloalkane as an initiator. Further a thermo-sensitive block copolymer of poly n-vinyl caprolactam (PNVCL) is obtained by polymerization of N-vinyl caprolactam (NVCL) monomers using the hydrophobic PBMA polymer as a macroinitiator.

The present disclosure provides an article. In an embodiment, the article includes a substrate and a coating on the substrate. The coating includes a composition. The composition includes a plurality of nanoparticles, each nanoparticle having a ligand linked to a surface of each nanoparticle. The composition includes a plurality of block copolymers. Each block copolymer includes a linking block and a nonlinking block. The linking block is a random copolymer composed of at least two different monomers. At least one of the monomers is a linking comonomer. The linking comonomer is directly linked to the ligand to form a first microdomain consisting of the linking block, the nanoparticles, and the ligand. The composition further includes a second microdomain consisting of the nonlinking block.

A chloroprene-based block copolymer, a latex, a latex composition, and a rubber composition that can produce a product with excellent flexibility and tensile properties without the use of a vulcanizing agent or a vulcanizing accelerator. A chloroprene-based block copolymer, includes 5 to 30% by mass of a polymer block (A) and 70 to 95% by mass of a chloroprene-based polymer block (B), wherein: the polymer block (A) is derived from a monomer; when the monomer is polymerized alone, a polymer with a glass transition temperature of 80° C. or higher can be obtained; the chloroprene-based polymer block (B) includes a chloroprene monomer; and the chloroprene-based block copolymer has a toluene insoluble content of 20 to 100% by mass with respect to 100% by mass of the chloroprene-based block copolymer.

A chloroprene-based block copolymer, a latex, a latex composition, and a rubber composition that can produce a product with excellent flexibility and tensile properties without the use of a vulcanizing agent or a vulcanizing accelerator. A chloroprene-based block copolymer, includes 5 to 30% by mass of a polymer block (A) and 70 to 95% by mass of a chloroprene-based polymer block (B), wherein: the polymer block (A) is derived from a monomer; when the monomer is polymerized alone, a polymer with a glass transition temperature of 80° C. or higher can be obtained; the chloroprene-based polymer block (B) includes a chloroprene monomer; and the chloroprene-based block copolymer has a toluene insoluble content of 20 to 100% by mass with respect to 100% by mass of the chloroprene-based block copolymer.

A block copolymer is provided that includes a first block having pendant phosphate and/or phosphonate groups and a second block that contains pendant poly(dialkylsiloxane) groups. Compositions containing the block copolymer as well as articles that include the block copolymer are also provided. The block copolymer can be used to provide a surface that is easy to clean and/or that is resistant to oil and grease without the use of fluorinated materials.

SiOC-linked, linear polydimethylsiloxane-polyoxyalkylene block copolymers of formula (I) C—B-(AB).sub.a—C1 are produced by reaction of end-equilibrated α,ω-diacetoxypolydimethylsiloxanes with a mixture including at least one polyether polyol, preferably a polyether diol, and at least one polyether monool or at least one monohydric alcohol.

SiOC-linked, linear polydimethylsiloxane-polyoxyalkylene block copolymers of formula (I) C—B-(AB).sub.a—C1 are produced by reaction of end-equilibrated α,ω-diacetoxypolydimethylsiloxanes with a mixture including at least one polyether polyol, preferably a polyether diol, and at least one polyether monool or at least one monohydric alcohol.

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.

Disclosed are methods for delivering a therapeutic or diagnostic agent to the cytosol of a cell in a subject. The disclosed methods generally include administering to the subject an effective amount of a lipid nanoparticle comprising the therapeutic or diagnostic agent and an effective amount of a membrane-destabilizing polymer. Also disclosed are related compositions and delivery systems.