A method for producing a block copolymer composition including a diblock copolymer and a triblock copolymer each containing a polyolefin-based block and a polystyrene-based block is disclosed herein. In some embodiments, the method includes reacting an organic zinc compound with one or more kinds of olefin-based monomers in the presence of a transition metal catalyst to form an intermediate having an olefin-based polymer block, reacting the intermediate styrene-based monomer in the presence of an alkyllithium compound to form a product having a styrene-based polymer block, and reacting the product with water, oxygen, or an organic acid to form a block copolymer wherein the number of moles of the alkyllithium compound used to form the product is larger than the number of moles of the organic zinc compound used to form the intermediate.

This present invention relates to a drug carrier comprising a polymer of γ-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal, and a method for preparing the same. It can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

This present invention relates to a drug carrier comprising a polymer of γ-glutamyl transpeptidase catalyzing hydrolysis-induced charge reversal, and a method for preparing the same. It can have a long circulation time in the blood, and can realize a charge reversal from negatively charged or the neutral to positively charged around the tumor blood vessel region, so that the positively charged polymer effectively penetrates deep into the tumor tissue, fast entering into the tumor cells, and greatly improves the therapeutic effect of the drug on the tumor. This overcomes the problems of slow diffusion of traditional polymer drug carriers in tumors and weak interaction with tumor cells, and has great significance in the field of anticancer treatment in the medical field.

To provide a conjugated diene graft polymer having high transparency, heat resistance and weather resistance, and a method for producing the conjugated diene graft polymer. A method for producing a conjugated diene graft polymer in which a side chain (b) including a polymer including at least one monomer unit selected from the group consisting of a conjugated diene unit and an aromatic vinyl compound unit is bonded to a main chain (a) including a polymer including a conjugated diene unit, via a hetero atom Z serving as a branching point and having a valence of not less than 3, the method including a step of reacting a specific active end polymer and a specific functional group-modified conjugated diene polymer having a functional group in a side chain to thereby produce a conjugated diene graft polymer; and a step of recovering the conjugated diene graft polymer obtained.

The present invention relates to a novel styrenic polymer comprised of the repeat units of structures (I), (II), and (III), wherein R.sub.1, R.sub.2 and R.sub.3 are individually selected from H or a C-1 to C-4 linear alkyl, R.sub.5, R.sub.7 and R.sub.6 are individually selected from a C-1 to C-8 linear alkyl, a C-3 to C-8 linear alkyl and a C-3 to C-8 cyclic alkyl and to the novel composition comprised of this polymer and a spin on organic solvent. In another aspect of this invention it pertains to the use of this composition to create a grafted on a substrate, and a further aspect, this grafted film may be used in a directed self-assembly process. ##STR00001##

A method of making functional polyisobutylene (PIB)-containing oligomers and polymers. By the disclosed method, the synthesis of functional PIB-containing polymers can be achieved directly under cationic polymerization conditions and does not include any post-polymerization reactions. The desired functionality is introduced by direct Electrophilic Aromatic Substitution (EAS) reaction using substituted phenyl ring carrying desirable functionalities that do not react with Lewis acid but have weak association with Lewis acid, which still allow living polymerization and EAS reaction under living cationic polymerization conditions. In the disclosed method functional polyisobutylene or isobutylene containing oligomers and polymers can be prepared using stoichiometric or near stoichiometric ratios of the capping or functionalization reagent to polymer end-chain.

A method of making functional polyisobutylene (PIB)-containing oligomers and polymers. By the disclosed method, the synthesis of functional PIB-containing polymers can be achieved directly under cationic polymerization conditions and does not include any post-polymerization reactions. The desired functionality is introduced by direct Electrophilic Aromatic Substitution (EAS) reaction using substituted phenyl ring carrying desirable functionalities that do not react with Lewis acid but have weak association with Lewis acid, which still allow living polymerization and EAS reaction under living cationic polymerization conditions. In the disclosed method functional polyisobutylene or isobutylene containing oligomers and polymers can be prepared using stoichiometric or near stoichiometric ratios of the capping or functionalization reagent to polymer end-chain.

The present invention relates to a novel styrenic polymer comprised of the repeat units of structures (I), (II), and (III), wherein R.sub.1, R.sub.2 and R.sub.3 are individually selected from H or a C-1 to C-4 linear alkyl, R.sub.5, R.sub.7 and R.sub.6 are individually selected from a C-1 to C-8 linear alkyl, a C-3 to C-8 linear alkyl and a C-3 to C-8 cyclic alkyl and to the novel composition comprised of this polymer and a spin on organic solvent. In another aspect of this invention it pertains to the use of this composition to create a grafted on a substrate, and a further aspect, this grafted film may be used in a directed self-assembly process.

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A resin composition for forming a phase-separated structure includes a block copolymer having a block (b1) formed of a repeating structure of styrene units, the block (b1) being partially substituted with a constituent unit represented by the following General Formula (c1) and a block (b2) having a repeating structure of methyl methacrylate units. In the formula, R is a hydrogen atom or a methyl group and R.sup.c0 is a hydrophobic functional group

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To provide a protein adsorption preventing agent having an excellent film forming property and excellent water solubility, capable of easily coating various substrates, and having an excellent protein adsorption preventing property, and also to provide a protein adsorption preventing film using the protein adsorption preventing agent and a medical tool including the protein adsorption preventing film. A protein adsorption preventing agent containing an aqueous solvent and a polymer having at least a structural unit (A) represented by the following formula (1) (wherein R.sup.1 represents a methyl group or an ethyl group and n represents an integer of 1 to 10), and further containing a hydrophobic group, a protein adsorption preventing film using the protein adsorption preventing agent, and a medical tool including the protein adsorption preventing film.

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