A tubulysin compound conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L.sup.D-D, the protein based recognition-molecule being connected to the polymeric carrier by L.sup.P. Each occurrence of D is independently a tubulysin compound having a molecular weight 5 kDa. L.sup.D and L.sup.P are distinct linkers connecting the tubulysin compound and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-tubulysin compound-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.

A method for producing an oxymethylene copolymer includes copolymerizing trioxane and a comonomer copolymerizable with the trioxane in a presence of a cationic polymerization catalyst and a polymerization controlling agent, wherein the polymerization controlling agent is a cyclic ether with a 4- or more-membered ring containing one oxygen atom.

A method for producing an oxymethylene copolymer includes copolymerizing trioxane and a comonomer copolymerizable with the trioxane in a presence of a cationic polymerization catalyst and a polymerization controlling agent, wherein the polymerization controlling agent is a cyclic ether with a 4- or more-membered ring containing one oxygen atom.

An aqueous adhesive composition comprises a phenol/aldehyde resin and less than 16% by weight of unsaturated diene elastomer latex. The phenol/aldehyde resin is based on an aromatic polyaldehyde bearing at least two aldehyde functional groups and comprising at least one aromatic nucleus, and on a polyphenol comprising one or more aromatic nuclei. If just one aromatic nucleus is present, the latter bears two or three hydroxyl functional groups in the meta position with respect to one another and the remainder of the aromatic nucleus is unsubstituted. If several aromatic nuclei are present, at least two of them each bear two or three hydroxyl functional groups in the meta position with respect to one another, it being understood that the two positions ortho to at least one of these hydroxyl functional groups are unsubstituted.

An aqueous adhesive composition comprises a phenol/aldehyde resin and less than 16% by weight of unsaturated diene elastomer latex. The phenol/aldehyde resin is based on an aromatic polyaldehyde bearing at least two aldehyde functional groups and comprising at least one aromatic nucleus, and on a polyphenol comprising one or more aromatic nuclei. If just one aromatic nucleus is present, the latter bears two or three hydroxyl functional groups in the meta position with respect to one another and the remainder of the aromatic nucleus is unsubstituted. If several aromatic nuclei are present, at least two of them each bear two or three hydroxyl functional groups in the meta position with respect to one another, it being understood that the two positions ortho to at least one of these hydroxyl functional groups are unsubstituted.

The present invention is directed to a method for producing an oxymethylene copolymer by subjecting trioxane and 1,3-dioxolane to copolymerization using boron trifluoride or a coordination compound thereof as a catalyst, wherein the copolymerization is conducted in the presence of a steric-hindrance phenol in an amount of 0.006 to 2.0% by weight, based on the weight of the trioxane, using 0.01 to 0.07 mmol of boron trifluoride or a coordination compound thereof as a catalyst, relative to 1 mol of the trioxane, and wherein, at a point in time when the polymerization yield becomes 92% or more, the formed oxymethylene copolymer and a polymerization terminator are contacted to terminate the polymerization.

The present invention is directed to a method for producing an oxymethylene copolymer by subjecting trioxane and 1,3-dioxolane to copolymerization using boron trifluoride or a coordination compound thereof as a catalyst, wherein the copolymerization is conducted in the presence of a steric-hindrance phenol in an amount of 0.006 to 2.0% by weight, based on the weight of the trioxane, using 0.01 to 0.07 mmol of boron trifluoride or a coordination compound thereof as a catalyst, relative to 1 mol of the trioxane, and wherein, at a point in time when the polymerization yield becomes 92% or more, the formed oxymethylene copolymer and a polymerization terminator are contacted to terminate the polymerization.

The present invention provides a method for producing a polydioxolane, which includes polymerizing a 1,3-dioxolane compound represented by the formula (1) in the presence of a cationic catalyst and a sterically hindered phenol in an amount of 10 to 1,500 ppm, based on the 1,3-dioxolane compound. In the formula (1), R1 to R6 are the same or difference and each independently represents a hydrogen atom, an alkyl group, an aryl group, a hydroxyalkyl group, an alkyloxy group, or an aryloxy group.

The present invention provides a method for producing a polydioxolane, which includes polymerizing a 1,3-dioxolane compound represented by the formula (1) in the presence of a cationic catalyst and a sterically hindered phenol in an amount of 10 to 1,500 ppm, based on the 1,3-dioxolane compound. In the formula (1), R1 to R6 are the same or difference and each independently represents a hydrogen atom, an alkyl group, an aryl group, a hydroxyalkyl group, an alkyloxy group, or an aryloxy group.

A method for molding amorphous polyether ether ketone including steps of preparing a molten mass including polyether ether ketone, cooling a mold assembly to a temperature of at most about 200 F., and injecting the molten mass into the cooled mold assembly.