The present disclosure generally relates to aerogel materials and methods for producing them.

Substrates comprising a functionalizable layer, a polymer layer comprising a plurality of micro-scale or nano-scale patterns, or combinations thereof, and a backing layer and the preparation thereof by using room-temperature UV nano-embossing processes are disclosed. The substrates can be prepared by a roll-to-roll continuous process. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.

Substrates comprising a functionalizable layer, a polymer layer comprising a plurality of micro-scale or nano-scale patterns, or combinations thereof, and a backing layer and the preparation thereof by using room-temperature UV nano-embossing processes are disclosed. The substrates can be prepared by a roll-to-roll continuous process. The substrates can be used as flow cells, nanofluidic or microfluidic devices for biological molecules analysis.

The present invention relates to an extrudable polymer composition comprising: 99.5 to 99.95% of at least one hard-soft block copolymer comprising: at least 25% by weight of soft block polyethylene glycol (PEG) with functionality equal to 2, with respect to the total weight in copolymer; from 0.05 to 0.5% by weight of at least one polyol comprising at least three hydroxyl groups, with respect to the total weight of the composition; characterised in that: the weight-average molecular mass of said copolymer is at least equal to 100,000 g/mol; and the weight-average molecular mass of the polyol is at least equal to 1000 g/mol; and said at least one polyol binding hard copolymer blocks by ester bonds. This invention relates in particular to the use of said composition in extrusion processes for manufacturing vapour-permeable objects.

The present invention relates to an extrudable polymer composition comprising: 99.5 to 99.95% of at least one hard-soft block copolymer comprising: at least 25% by weight of soft block polyethylene glycol (PEG) with functionality equal to 2, with respect to the total weight in copolymer; from 0.05 to 0.5% by weight of at least one polyol comprising at least three hydroxyl groups, with respect to the total weight of the composition; characterised in that: the weight-average molecular mass of said copolymer is at least equal to 100,000 g/mol; and the weight-average molecular mass of the polyol is at least equal to 1000 g/mol; and said at least one polyol binding hard copolymer blocks by ester bonds. This invention relates in particular to the use of said composition in extrusion processes for manufacturing vapour-permeable objects.

A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery. ##STR00001##

A variety of hydrophobically modified polypeptoids are provided. The hydrophobically modified polypeptoids can include a polyamide backbone having a random copolymer of two or more different types of repeat units, where one or more of the repeat units have nitrogen atom having a hydrophobic substituent attached thereto. Methods of making the hydrophobically modified polypeptoids are also provided, as well as uses of the hydrophobically modified polypeptoids, for example in liposomal drug delivery. ##STR00001##

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

Techniques regarding polymers with antimicrobial functionality are provided. For example, one or more embodiments described herein can regard a polymer, which can comprise a repeating ionene unit. The repeating ionene unit can comprise a cation distributed along a degradable backbone. The degradable backbone can comprise a terephthalamide structure. Further, the repeating ionene unit can have antimicrobial functionality.

Disclosed is a dianhydride having Formula I, and diamines having Formula IV and Formula VII

##STR00001##

In the formulas: Y is alkyl, silyl, ester, siloxane, oligosiloxane, polysiloxane, O, S, SO.sub.2, BR.sup.3, NR.sup.3, P(O)R.sup.3, unsubstituted or substituted carbocyclic aryl, or unsubstituted or substituted heteroaryl and deuterated analogs thereof; Ar.sup.2-Ar.sup.4 are the same or different and are carbocyclic aryl, heteroaryl, or substituted derivatives thereof; Q.sup.1 is a single bond, alkyl, silyl, ester, siloxane, oligosiloxane, polysiloxane, O, S, SO.sub.2, BR.sup.3, NR.sup.3, P(O)R.sup.3, unsubstituted or substituted carbocyclic aryl, or unsubstituted or substituted heteroaryl and deuterated analogs thereof; R.sup.1-R.sup.2 are the same or different at each occurrence and are F, CN, deuterium, alkyl, fluoroalkyl, unsubstituted or substituted carbocyclic aryl, unsubstituted or substituted heteroaryl, alkoxy, fluoroalkoxy, unsubstituted or substituted aryloxy, silyl, siloxy and deuterated analogs thereof; R.sup.3 is alkyl or unsubstituted or substituted carbocyclic aryl; a and b are the same or different and are an integer from 0-5; and c is 0 or 1.