The present invention relates to polymeric nanoparticles comprising a pharmaceutical combination, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.

The present invention relates to polymeric nanoparticles comprising a pharmaceutical combination, pharmaceutical compositions comprising the same, and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.

Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.

Disclosed are copolymer micelles for simultaneous delivery of Cas9 mRNA and guide RNA for Cas9 CRISPR gene editing. Also disclosed are copolymer micelles for simultaneous delivery of a therapeutic or diagnostic nucleic acid and a cross-linking or alkylating anticancer agent.

The present invention relates to cross polymers composed at least of polysaccharides and polyamino acids, and more particularly to hydrogels composed of said cross polymers. The invention also relates to a process for preparing them, as well as their use in the delivery of active agents for pharmaceutical, diagnostic and/or dermo-cosmetic applications.

The present invention relates to cross polymers composed at least of polysaccharides and polyamino acids, and more particularly to hydrogels composed of said cross polymers. The invention also relates to a process for preparing them, as well as their use in the delivery of active agents for pharmaceutical, diagnostic and/or dermo-cosmetic applications.

The present invention relates to a dispersant derived from anhydride functionalized polyester derived from carboxylic acid functionalized polyester. The anhydride functionalized polyester is then reacted with a multi-amine species forming amide and salt bonds. The technology allows lower reaction temperatures when the multi-amine species is present. The lower reaction temperature allows the use of a broader selection of polyester repeat units.

The invention relates to a branched copolymer containing rigid blocks and flexible blocks, wherein the branchings are made by a polyol residue binding rigid blocks of the copolymer, said polyol being a polyol comprising at least three hydroxyl groups, said copolymer having a weight-average molar mass Mw of greater than or equal to 80 000 g/mol, and wherein the ratio of the weight-average molar mass Mw of the copolymer to the number-average molar mass Mn of the copolymer is greater than or equal to 2.2.

The invention also relates to a process for manufacturing such a copolymer and also to a foam of such a copolymer, to a process for manufacturing such a foam and articles made from such a foam.