In various embodiments a polyrotaxane carrier for in vivo delivery of a nucleic acid is provided. In certain embodiments the carrier comprises: a multi-arm polyethylene glycol (PEG) backbone comprising at least three arms; at least one cyclic compound having a cavity, where an arm of said multi-arm PEG backbone is threaded into the cavity of said cyclic compound forming an inclusion complex; a bulky moiety capping the terminal of the arm(s) threaded into said cyclic compound where said moiety inhibits dethreading of the cyclodextrin from the arm(s) of said backbone; and where at least one arm of said PEG backbone is free of cyclic compounds; and where said carrier has a net positive charge.

The present disclosure provides an anisotropic conductive film, a display panel, and manufacturing method thereof. The anisotropic conductive film includes a conductive particle, the conductive particle including a covalent organic framework material, the covalent organic framework material including PyVg-COF. The display panel including a first substrate, a second substrate and an anisotropic conductive film. The method of manufacturing the display panel including: providing a first substrate, coating an anisotropic conductive film on the first substrate, coupling the second substrate to the first substrate, and bonding the first substrate to the second substrate. The present disclosure provides the conductive particles of the covalent organic frame material replace the existing gold ball as an anisotropic conductive film for bonding, thereby saving the manufacturing cost of the gold ball, improving the conductivity and water resistance, and avoiding the bonding contact point being oxidation.

The present disclosure provides an anisotropic conductive film, a display panel, and manufacturing method thereof. The anisotropic conductive film includes a conductive particle, the conductive particle including a covalent organic framework material, the covalent organic framework material including PyVg-COF. The display panel including a first substrate, a second substrate and an anisotropic conductive film. The method of manufacturing the display panel including: providing a first substrate, coating an anisotropic conductive film on the first substrate, coupling the second substrate to the first substrate, and bonding the first substrate to the second substrate. The present disclosure provides the conductive particles of the covalent organic frame material replace the existing gold ball as an anisotropic conductive film for bonding, thereby saving the manufacturing cost of the gold ball, improving the conductivity and water resistance, and avoiding the bonding contact point being oxidation.

A composition of matter including a crosslinked bottlebrush polymer, wherein the crosslinker units in the composition of matter are soluble with the bottlebrush polymer. In one example, the crosslinked bottlebrush polymer is tailored as a single phase (solvent free) elastomer useful in a capacitive pressure sensing device. A novel embodiment of the present invention further includes demonstration of a universal approach to form solvent-free bottlebrush polymer networks by photo-crosslinking mixtures of well-defined bottlebrush precursors and bis-benzophenone-based additives. This method has been proven effective with a wide variety of different side-chain chemistries.

Disclosed herein are polymers, copolymers and polymer systems based on polypropiolactones which can be biodegradable and can enhance the recyclability of polymer systems, which can be functionalized to introduce desired functionality into the polymers and/or which may optionally be prepared from renewable raw materials. Disclosed are novel functionalized beta propiolactones. Some of the novel functionalized beta propiolactones have functional groups bound to the ring structure of the lactone that provide improved polymer systems. Disclosed are novel homopolymers of the functionalized beta propiolactones. Disclosed are novel copolymers based on the functionalized beta propiolactones with beta propiolactone or other monomers which copolymerize with the functionalized beta propiolactones.

The present invention relates to a targeting-type capsule for drug delivery systems. The present invention addresses the problem of providing a capsule for drug delivery systems by utilizing the reactivity of a thiol with an alkyl halide, wherein the capsule comprises a silole-containing carbosilane dendrimer and a labeling protein containing a target recognition site (e.g., green fluorescent protein), can include a biological polymer or another molecule therein, and can deliver the biological polymer or the like selectively into a target cell.

Xerogels and compositions comprising xerogels comprising a transition metal oxide and silicon oxide xerogel matrix. The xerogels and compositions can be made from mixtures of transition metal alkoxide(s) and tetraalkoxysilane(s) and, optionally, alkyltrialkoxysilane(s), aminoalkyl-, alkylaminoalkyl-, dialkylaminoalkyltrialkoxysilane(s), or a combination thereof. The xerogels and compositions can be used as antifouling coatings on, for example; boats.

Provided herein is a dendrimer comprising: i) a core unit (C); and ii) building units (BU), wherein the core unit is covalently attached to at least two building units; the dendrimer having from two to six generations of building units; wherein building units of different generations are covalently attached to one another; and the dendrimer further comprising: iii) one or more first terminal groups attached to an outermost building unit, wherein each first terminal group comprises a radionuclide-containing moiety; and iv) one or more second terminal groups attached to an outermost building unit, wherein each second terminal group comprises a pharmacokinetic-modifying moiety; or a salt thereof. Also provided are compositions comprising the dendrimers, and methods of using the dendrimers and compositions in diagnostic and therapeutic applications.

The present invention relates to the unexpected discovery of novel hybrid molecular brush (HMB) polymers and materials that are able to alter their characteristics based on the surrounding solvent properties. In certain embodiments, the HMBs are amphiphilic, comprising a backbone, at least one hydrophilic side-chain, and at least one hydrophobic side-chain. In another aspect, the invention relates to methods of making the HMBs of the invention.

One-pot synthetic methods are disclosed for synthesizing curable, antimicrobial silsesquioxane-silica hybrids by hydrolytically co-condensing a tetraalkoxysilane with two different trialkoxysilanes. Particles are also disclosed that are substantially spherical and have an ordered lamellar internal structure. In addition, polymers prepared from the curable, antimicrobial silsesquioxane-silica hybrids and co-monomers are disclosed.