The invention provides polymer compositions, compounds, processes, and methods of use of the polymers for drug delivery, biodegradable consumer plastics, or solvents for Li-based batteries or supercapacitors. The invention is based, at least in part, on the discovery that poly(glyceric acid carbonate)s and alkyl functionalized poly(1,2 glycerol carbonates) and poly(glyceric acid carbonate)s and pharmaceutical agent/composition functionalized poly(1,2 glycerol carbonates) and poly(glyceric acid carbonate)s represent a new type of glycerol based polymer that 1) degrade into glycerol and carbon dioxide; 2) the poly(1,2 glycerol carbonates) degrade more readily than conventional poly(1,3 glycerol carbonates; and 3) poly(1,2 glycerol carbonates) can be processed to give melts, viscous fluids, liquids, films, sheets, gels, meshes, foams, fibers, or particles.

Disclosed herein are degradable materials comprising the reaction product of an oxanorbornadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbornadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.

A biodegradable foam which includes a polyester-based polyurethane foam and a mixture comprised of a soil-dwelling carbon-digesting bacteria embedded in a carrier compound. The mixture of the soil-dwelling carbon-digesting bacteria is homogenously dispersed throughout the polyester-based polyurethane foam. This biodegradable foam exhibits biodegradation rates higher than a polyester-based polyurethane foam absent the soil-dwelling carbon-digesting bacteria.

Provided is a degradable microparticle with a grain size in a range of 2 micrometers to 1400 micrometers, and the degradable microparticle comprises poly(glycerol sebacate), poly(glycerol maleate), poly(glycerol succinate-co-maleate), poly(glycerol succinate), poly(glycerol malonate), poly(glycerol glutarate), poly(glycerol adipate), poly(glycerol pimelate), poly(glycerol suberate), poly(glycerol azelate), or any combination thereof. A degradable product produced from the degradable microparticles can obtain the desired degradation effect and can be produced by chemical synthesis to reduce the production cost. With these advantages, the applicability of the degradable microparticles is improved.

The present invention may provide a composition containing a biologically degradable resin from which a molded article having suppressed deterioration of the tensile strength and the elongation at the breaking point thereof can be obtained. The present invention may provide a resin composition including a biologically degradable resin, a heavy calcium carbonate, and acetyl tributyl citrate, in which a mass ratio of the biologically degradable rein to the heavy calcium carbonate is 10:90 to 70:30, the biologically degradable resin includes at least polybutylene adipate terephthalate or polybutylene succinate adipate, a content of the polybutylene adipate terephthalate or the polybutylene succinate adipate relative to the biologically degradable resin is 70% or more by mass, and a content of the acetyl tributyl citrate relative to the resin composition is 5.0% or more and 20.0% or less by mass.

A biopolymer, which exists in a liquid phase at room temperature, a use thereof, and a preparation method therefor are provided.

Embodiments of the disclosure generally provide compositions and methods related to oligomeric and polymeric urethane materials that contain hydrolyzable polythioaminal groups for use in biomedical applications.

This invention relates to a biodegradable copolyester composition, comprising: a) from 40 to 60 mol %, based on total mole of a) and b), of aromatic dicarboxylic acid selected from benzene dicarboxylic acid or ester derivative of said acid; b) from 40 to 60 mol %, based on total mole of a) and b), of a mixture of aliphatic dicarboxylic acid, wherein b) comprising: b1) from 20 to 80 mol %, based on mole of b), of at least one aliphatic dicarboxylic acid having 2 to 6 carbon atoms; and b2) from 20 to 80 mol %, based on mole of b), of at least one aliphatic dicarboxylic acid having 7 to 14 carbon atoms; c) at least one mole equivalent, based on total mole of a) and b), of diol having 2 to 6 carbon atoms; and d) from 0.1 to 2.0 mole % based on total mole of a), b), c), and d), of alcohol with at least 3 hydroxyl groups. The biodegradable copolyester composition according to this invention has improved thermal property, mechanical property, and biodegradability.

Provided is an aliphatic polyester composition. The aliphatic polyester composition comprises a polybutylene succinate, wherein the proton nuclear magnetic resonance of the aliphatic polyester composition has a first characteristic peak and a second characteristic peak. The first characteristic peak is located between 3.84 ppm and 4.32 ppm, and the second characteristic peak is located between 5.65 ppm and 5.85 ppm. The integral value of the first characteristic peak is set to be 100 and the integral value of the second characteristic peak is less than 0.10. By controlling the integral value of the second characteristic peak in H.sup.1-NMR of the aliphatic polyester composition, the aliphatic polyester composition has good appearance and low concentration of carboxylic acid end group and thereby the product value thereof is increased.

The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I

##STR00001##

wherein R.sup.1, R.sup.2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.