The present application relates to a polymer composite capable of being quickly dissolved or dispersed in an aqueous solvent, and a preparation method and an application thereof. The polymer composite includes a polymer capable of being thermodynamically dissolved in water or an aqueous solvent and a dispersant containing an ion capable of coordinating with the polymer. The polymer is selected from the group of a water soluble homopolymer and/or copolymer, in particular, thermogelable amphiphilic copolymer.

The method is described herein for forming a polymer, comprising providing a first monomer comprising a polyol having at least two hydroxyl groups; providing a second monomer comprising a polyalkyl ester of a polycarboxylic acid having at least two alkyl ester groups; mixing the first monomer and the second monomer to form a reaction mixture; and reacting the first monomer and the second monomer in the mixture by transesterification to form a polyester polymer, which may, if desired be crosslinked. The polymers may also be copolymerized with other monomers. Polymers and copolymers formed from the method herein, as well as articles formed therefrom are also described. Such polymers and articles may be biocompatible and/or bioresorbable.

The present invention relates to poly(alkylene terephthalate) polyesters having long poly-methylene segments and their use in a wide variety of applications. Particularly, said PAT polyesters are used in biotechnological or biomedical applications, wherein the extent of cell adhesion, cell growth or cell interaction, in particular endothelial cells, depends on the odd or even number of carbon atoms in the aliphatic segments. Also provided are methods for the preparation of poly(alkylene terephthalates) (PAT) having long poly-methylene segments, wherein the bifunctional monomers, in particular terephthalic acid (or a derivative thereof) and an aliphatic diol, are dissolved in a solvent and the polycondensation reaction takes place in solution.

Disclosed in the present invention is a semiaromatic polyester, a preparation method and application thereof. Having a specific segment length and carboxyl group content, the semiaromatic polyester provides a balance of degradation rate and mechanical properties, compared with known semiaromatic polyesters. The 30-day weight retention of the semiaromatic polyester obtained in the present invention may be contained to from 45 to 70%.

Residence structures, systems, and related methods are generally provided. Certain embodiments comprise administering (e.g., orally) a residence structure to a subject (e.g., a patient) such that the residence structure is retained at a location internal to the subject for a particular amount of time (e.g., at least about 24 hours) before being released. The residence structure may be, in some cases, a gastric residence structure. In some embodiments, the structures and systems described herein comprise one or more materials configured for high levels of active substances (e.g., a therapeutic agent) loading, high active substance and/or structure stability in acidic environments, mechanical flexibility and strength in an internal orifice (e.g., gastric cavity), easy passage through the GI tract until delivery to at a desired internal orifice (e.g., gastric cavity), and/or rapid dissolution/degradation in a physiological environment (e.g., intestinal environment) and/or in response to a chemical stimulant (e.g., ingestion of a solution that induces rapid dissolution/degradation). In certain embodiments, the structure has a modular design, combining a material configured for controlled release of therapeutic, diagnostic, and/or enhancement agents with a structural material necessary for gastric residence but configured for controlled and/or tunable degradation/dissolution to determine the time at which retention shape integrity is lost and the structure passes out of the gastric cavity. For example, in certain embodiments, the residence structure comprises a first elastic component, a second component configured to release an active substance (e.g., a therapeutic agent), and, optionally, a linker. In some such embodiments, the linker may be configured to degrade such that the residence structure breaks apart and is released from the location internally of the subject after a predetermined amount of time.

The present specification generally relates to a composition for the manufacture of ocean degradable, bio-degradable, bio-compostable, biocompatible articles that contain a bio-based thermoplastic component. More specifically, the present invention relates to an aliphatic polyester resin composition comprising: (i) a polyhydroxyalkanoate (PHA) in the range of 100%-51% by weight in combination with (ii) a semiconductor in the range of 0%-49% by weight, and (iii) an additive in the range of 0% to about 75% by weight of the total composition; and the subsequent manufacture of articles formed using the aliphatic polyester resin composition.

This invention relates to a new polyester which is particularly suitable for use in the manufacture of mass-produced articles characterised by excellent mechanical properties, in particular high tensile strength and tensile modulus, associated with a high barrier property against oxygen and carbon dioxide.

The present invention describes a process of manufacturing biodegradable PET chips, comprising the steps of providing a purified terephthalic acid (PTA) in a predetermined quantity in a slurry tank; providing virgin monoethylene glycol (MEG) in a predetermined quantity in the slurry tank; transferring the combination of the slurry tank to an esterification reactor for esterification of the combination in the reactor at above 250° C. temperature which releases monomers; transferring the monomers from the esterification reactor to a polymerisation reactor; providing poly-catalysts such as, but not limited, to Ti-based catalyst, sb2O3 or any other suitable catalysts or combination thereof into the polymerisation reactor; and polymerization of the monomers in the polymerisation reactor at above 280° C. temperature, wherein an enzyme based composition is provided either at PTA/MEG stage or poly-catalyst stage or at other stages or combination thereof.

Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.

The invention provides for novel thermo-responsive polymers and compositions comprising the same. In some embodiments, the polymers are water soluble, pH-degradable and have tunable lower critical solution temperatures. Other aspects of the invention include micelles and gels comprising the thermo-responsive polymers and derivatives thereof, as well as methods of delivering therapeutic agents comprising administering a biodegradable gel or micelle comprising a polyacetal compound cross-linked with a linker.