The present disclosure relates to thermoplastic protein elastomer compositions comprising protein, at least one reactive thermoplastic elastomer, and at least one softener, as well as composite materials made from these compositions. Methods of making and using the thermoplastic protein elastomer composite materials to produce engineered leather are also disclosed. In some embodiments, the protein is selected from the group consisting of: soy protein, cellulase, zein protein, egg white albumin, and pea protein; and wherein the protein and the thermoplastic elastomer are not covalently bound together. In some embodiments, the protein and the thermoplastic elastomer are present in co-continuous phases.