The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β-tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.

The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β-tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to handle in printing nozzle without clogging and to obtain a good resolution. Cellulose nanofibrils can be produced by bacteria orbe isolated from plants. They can be neutral, charged or oxidized to be biodegradable. The bioink can be additionally supplemented by other biopolymers which provide crosslinking. Such biopolymers can be alginates, chitosans, modified hyaluronic acid or modified collagen derived biopolymers.

Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.

Tissue engineering devices and methods employing scaffolds made of absorbable material for use in the human body for tissue genesis and regenerative and cellular medicine including breast reconstruction and cosmetic and aesthetic procedures and supplementing organ function in vivo.

An organic slurry for use in wood-based composites is described herein. In one aspect, the organic slurry may include water, a lignin material insoluble in the water, such as dewatered kraft lignin, and a defoamer. During manufacturing, the water, lignin material and defoamer may be combined and mixed together in a vessel to produce the organic slurry. In one aspect, the defoamer may include a water-based defoamer, a silicone-based defoamer, a silicone-free defoamer, an oil-based defoamer, a polymer-based defoamer, or mixtures thereof. The organic slurry may have a pH less than neutral.

An organic slurry for use in wood-based composites is described herein. In one aspect, the organic slurry may include water, a lignin material insoluble in the water, such as dewatered kraft lignin, and a defoamer. During manufacturing, the water, lignin material and defoamer may be combined and mixed together in a vessel to produce the organic slurry. In one aspect, the defoamer may include a water-based defoamer, a silicone-based defoamer, a silicone-free defoamer, an oil-based defoamer, a polymer-based defoamer, or mixtures thereof. The organic slurry may have a pH less than neutral.

A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.

A paravalvular leak resistant prosthetic heart valve system including a stent frame, a valve structure and a sealing mechanism. The stent frame has a surface. The valve structure is associated with the stent frame. The sealing mechanism at least partially extends over the surface of the stent frame. The sealing mechanism includes at least one semi-permeable membrane and an osmotic gradient driving material.

The present invention relates to the use of an amine compound comprising at least one, preferably at least two amine functions, wherein the amine functions are primary or secondary amines, to reduce the level of furfural and/or hydroxymethylfurfural in a carbohydrate-based binder or binder composition and/or escaping in the course of preparation, cross-linking and/or curing of carbohydrate-based binders. Preferably, the carbohydrate-based binder is obtained from a carbohydrate-based binder composition comprising a carbohydrate component and a cross-linker and possibly reaction product of carbohydrate component and cross-linker, wherein the cross-linker is selected from ammonium salts of inorganic acid, carboxylic acids, salts, ester or anhydride derivatives thereof, and/or combinations thereof.

The present invention relates to the use of an amine compound comprising at least one, preferably at least two amine functions, wherein the amine functions are primary or secondary amines, to reduce the level of furfural and/or hydroxymethylfurfural in a carbohydrate-based binder or binder composition and/or escaping in the course of preparation, cross-linking and/or curing of carbohydrate-based binders. Preferably, the carbohydrate-based binder is obtained from a carbohydrate-based binder composition comprising a carbohydrate component and a cross-linker and possibly reaction product of carbohydrate component and cross-linker, wherein the cross-linker is selected from ammonium salts of inorganic acid, carboxylic acids, salts, ester or anhydride derivatives thereof, and/or combinations thereof.