The present invention encompasses methods and compositions for generating a biomimetic proteoglycan. The invention includes methods of treating a disease, disorder, or condition of soft tissue using a biomimetic proteoglycan.

The present invention provides topical dosages and formulations of lidocaine and pharmaceutically acceptable salts thereof, which are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly for debridement pain, and increase the duration of pain relief, and thereby provide more effective treatment to chronic open wounds, particularly those in non-mucosal tissue.

The present invention provides topical dosages and formulations of lidocaine and pharmaceutically acceptable salts thereof, which are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly for debridement pain, and increase the duration of pain relief, and thereby provide more effective treatment to chronic open wounds, particularly those in non-mucosal tissue.

The present disclosure discloses a modified hydroxypropyl methyl cellulose for an enhanced ceramic tile adhesive, which is prepared from the following raw materials by mass percent: 54%-94% of hydroxypropyl methyl cellulose, 5%-40% of starch ether, 0.5%-3% of dispersing agent and 0.5%-3% of rheological agent, wherein the hydroxypropyl methyl cellulose is prepared from cellulose powder, granular caustic soda, liquid caustic soda, chloromethane and propylene oxide. A preparation method includes: (1) weighing the raw materials; (2) mixing the cellulose powder, the granular caustic soda, the liquid caustic soda, the chloromethane and the propylene oxide, carrying out etherification reaction, and then sequentially carrying out neutralization, washing, centrifugation, drying and crushing to obtain the hydroxypropyl methyl cellulose; and (3) mixing and stirring the hydroxypropyl methyl cellulose, the starch ether, the dispersing agent and the rheological agent to obtain the modified hydroxypropyl methyl cellulose.

The present disclosure discloses a modified hydroxypropyl methyl cellulose for an enhanced ceramic tile adhesive, which is prepared from the following raw materials by mass percent: 54%-94% of hydroxypropyl methyl cellulose, 5%-40% of starch ether, 0.5%-3% of dispersing agent and 0.5%-3% of rheological agent, wherein the hydroxypropyl methyl cellulose is prepared from cellulose powder, granular caustic soda, liquid caustic soda, chloromethane and propylene oxide. A preparation method includes: (1) weighing the raw materials; (2) mixing the cellulose powder, the granular caustic soda, the liquid caustic soda, the chloromethane and the propylene oxide, carrying out etherification reaction, and then sequentially carrying out neutralization, washing, centrifugation, drying and crushing to obtain the hydroxypropyl methyl cellulose; and (3) mixing and stirring the hydroxypropyl methyl cellulose, the starch ether, the dispersing agent and the rheological agent to obtain the modified hydroxypropyl methyl cellulose.

The present disclosure discloses a modified hydroxyethyl methyl cellulose for an enhanced ceramic tile adhesive, which is prepared from the following raw materials by mass percent: 54%-94% of hydroxyethyl methyl cellulose, 5%-40% of starch ether, 0.5%-3% of dispersing agent and 0.5%-3% of rheological agent, wherein the hydroxyethyl methyl cellulose is prepared from cellulose powder, granular caustic soda, liquid caustic soda, chloromethane and ethylene oxide. A preparation method includes: (1) weighing the raw materials; (2) mixing the cellulose powder, the granular caustic soda, the liquid caustic soda, the chloromethane and the ethylene oxide, carrying out etherification reaction, and then sequentially carrying out neutralization, washing, centrifugation, drying and crushing to obtain the hydroxyethyl methyl cellulose; and (3) mixing and stirring the hydroxyethyl methyl cellulose, the starch ether, the dispersing agent and the rheological agent to obtain the modified hydroxyethyl methyl cellulose.

The present disclosure discloses a modified hydroxyethyl methyl cellulose for an enhanced ceramic tile adhesive, which is prepared from the following raw materials by mass percent: 54%-94% of hydroxyethyl methyl cellulose, 5%-40% of starch ether, 0.5%-3% of dispersing agent and 0.5%-3% of rheological agent, wherein the hydroxyethyl methyl cellulose is prepared from cellulose powder, granular caustic soda, liquid caustic soda, chloromethane and ethylene oxide. A preparation method includes: (1) weighing the raw materials; (2) mixing the cellulose powder, the granular caustic soda, the liquid caustic soda, the chloromethane and the ethylene oxide, carrying out etherification reaction, and then sequentially carrying out neutralization, washing, centrifugation, drying and crushing to obtain the hydroxyethyl methyl cellulose; and (3) mixing and stirring the hydroxyethyl methyl cellulose, the starch ether, the dispersing agent and the rheological agent to obtain the modified hydroxyethyl methyl cellulose.

Provided is a low-molecular-weight holothurian glycosarninoglycan, with the constituent units thereof being a glucuronic acid group, an N-acetaminogalactose group and a fucose group, and a sulfate ester group or acetyl ester group thereof. Glucuronic acid and N-acetaminogalactose are interconnected via β(1-3) and β(1-4) glucosidic bonds to form a backbone of a disaccharide repeating structural unit, and a fucose group is connected to the backbone as a side chain. On a molar ratio basis, the ratio of the glucuronic acid group:the N-acetaminogalactose group:the fucose group is 1:(0.8-1.2):(0.6-1.2). In the structure of the low-molecular-weight holothurian glycosaminoglycan, 10-30% of glucuronic acid groups are modified, on the 2-position, with a sulfate ester group, and the rest are hydroxyl groups; and a proportion of 10-30% of fucose groups is modified, on the 2-position, with an acetyl ester group, and the rest are hydroxyl or sulfate ester groups. The low-molecular-weight holothurian glycosarninoglycan of the present invention has anti-inflammation, anti-vasculopathy, anti-tumor or anti-tumor-metastasis functions, and the effect of improving learning and memory abilities, and can be used for preparing a related drug or health-care product.

Disclosed herein is a method for producing modified gum arabic, the method comprising: providing gum arabic; heating said gum arabic, resulting in heat-treated gum arabic; dissolving said heat-treated gum arabic in a solution; optionally, filtering said solution containing said dissolved gum arabic; and subjecting said solution containing said dissolved gum arabic to spray-drying. Further disclosed herein is a gum arabic from Acacia Senegal having (i) a weight average molecular weight (M.sub.w) of ≥3.8.Math.10.sup.6 Da, and/or (ii) a RMS-radius of gyration (R.sub.g) of ≥140 nm.

Disclosed herein are polysaccharide-elastomer masterbatch compositions and processes for preparing the masterbatch compositions. One method comprises a step of a) mixing i) an aqueous polysaccharide dispersion, or ii) a basic aqueous polysaccharide solution, with a rubber latex solution containing a rubber component to form a mixture. The method further comprises the steps of: b) coagulating the mixture obtained in step a) to produce a coagulated mass; and c) drying the coagulated mass obtained in step b). The masterbatch compositions are useful in preparing rubber-containing articles.