Cyclooxygenase-2 (COX-2) over-expression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX-2 activity within its native environment poses an exciting approach to account for and illuminate the effect of the local environments on protein activity. Herein, we report the development of CoxFluor, the first activity-based sensing approach for monitoring COX-2 within live cells with confocal microscopy and flow cytometry. CoxFluor strategically links a natural substrate with a dye precursor to engage both the cyclooxygenase and peroxidase activities of COX-2. This catalyzes the release of resorufin and the natural product, as supported by molecular dynamics and ensemble docking. CoxFluor enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protein expression within live macrophage cells.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and/or hosts on basis of benzotriazoles, which have a sufficiently small energy gap between S.sub.1 and T.sub.1 (?E.sub.ST) to enable up-conversion of the triplet exciton from T.sub.1 to S.sub.1. The organic light emitting elements show high electroluminescent efficiency.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and/or hosts on basis of benzotriazoles, which have a sufficiently small energy gap between S.sub.1 and T.sub.1 (?E.sub.ST) to enable up-conversion of the triplet exciton from T.sub.1 to S.sub.1. The organic light emitting elements show high electroluminescent efficiency.

An infrared-sensitive color developing composition develops colors in a high density with an infrared exposure and does not significantly discolor when aged. A lithographic printing plate precursor which has extremely excellent plate-inspecting properties and favorable storage stability and is capable of maintaining favorable color-developing properties is provided, as is a plate making method for a lithographic printing plate in which the lithographic printing plate precursor is used. A new compound that can be preferably used as an infrared-sensitive color developer is also provided. An infrared-sensitive color developing composition of the invention includes a compound represented by Formula (1) (Component A). In addition, the compound in the present invention is represented by Formula (1). ##STR00001##

The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.

The presently-disclosed subject matter includes azetidine-substituted fluorescent compounds, where the compounds may be used as probes, dyes, tags, and the like. The presently-disclosed subject matter also includes kits comprising the same as well as methods for using the same to detect a target substance.

Described herein are photonic crystals comprising a plurality of substantially uniform zein particles. The photonic crystals can be fabricated by assembling the plurality of substantially uniform zein particles into one or more ordered and periodic structures that generate structural color. Also described herein are methods of using the photonic crystals described herein, e.g., as colorants in consumer products, such as food, drugs and/or cosmetics.

Described herein are photonic crystals comprising a plurality of substantially uniform zein particles. The photonic crystals can be fabricated by assembling the plurality of substantially uniform zein particles into one or more ordered and periodic structures that generate structural color. Also described herein are methods of using the photonic crystals described herein, e.g., as colorants in consumer products, such as food, drugs and/or cosmetics.

The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.

The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or glycopeptides.