Disclosed herein are compounds, conjugates, and methods that may be used to detect the presence of an analyte in a sample, such as a biological sample.

The invention provides fluorescent probes having the general formula (I)

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wherein X, Y, L and R.sup.1 to R.sup.4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture.

Methods, systems, and apparatus for monitoring and controlling electronic devices using wired and wireless protocols are disclosed. The systems and apparatus may monitor their environment for signals from electronic devices. The systems and apparatus may take and disambiguate the signals that are received from the devices in their environment to identify the devices and associate control signals with the devices. The systems and apparatus may use communication means to send control signals to the identified electronic devices. Multiple apparatuses or systems may be connected together into networks, including mesh networks, to make for a more robust architecture.

A photosensitive coloring composition includes a magenta pigment having an average primary particle diameter of 50 nm or less, a polymerizable compound, a photopolymerization initiator, and an ultraviolet absorber, in which the magenta pigment has a maximum absorption wavelength in a range of 500 to 600 nm, and in a case where an absorbance of the maximum absorption wavelength is 1, a wavelength at which an absorbance is 0.5 is 450 nm or more on a side where a wavelength is shorter than the maximum absorption wavelength and is 650 nm or less on a side where a wavelength is longer than the maximum absorption wavelength.

A photosensitive coloring composition includes a magenta pigment having an average primary particle diameter of 50 nm or less, a polymerizable compound, a photopolymerization initiator, and an ultraviolet absorber, in which the magenta pigment has a maximum absorption wavelength in a range of 500 to 600 nm, and in a case where an absorbance of the maximum absorption wavelength is 1, a wavelength at which an absorbance is 0.5 is 450 nm or more on a side where a wavelength is shorter than the maximum absorption wavelength and is 650 nm or less on a side where a wavelength is longer than the maximum absorption wavelength.

Disclosed herein are compounds or salts and/or solvates of formula I, II and III, where the compounds or salts and/or solvates have the following structures: (X).sub.a—Y—(Z).sub.b I; II; or X′—Y′ III; where X, Y, Z, Y′, a, b, R.sub.4, R.sub.6 and R.sub.7 are as defined herein.

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Cyclooxygenase-2 (COX-2) over-expression is prominent in inflammatory diseases, neurodegenerative disorders, and cancer. Directly monitoring COX-2 activity within its native environment poses an exciting approach to account for and illuminate the effect of the local environments on protein activity. Herein, we report the development of CoxFluor, the first activity-based sensing approach for monitoring COX-2 within live cells with confocal microscopy and flow cytometry. CoxFluor strategically links a natural substrate with a dye precursor to engage both the cyclooxygenase and peroxidase activities of COX-2. This catalyzes the release of resorufin and the natural product, as supported by molecular dynamics and ensemble docking. CoxFluor enabled the detection of oxygen-dependent changes in COX-2 activity that are independent of protein expression within live macrophage cells.

Provided are far red to near-infrared nerve-sparing fluorescent compounds, compositions comprising them, and methods of their use in medical procedures.

The presence of mild electrophiles, such as aldehydes, during the denaturation of glycoproteins or glycopeptides and subsequent enzymatic deglycosylation reduces artifacts in subsequent analyses of the glycans released from the glycoproteins or gly-copeptides.