A method for producing water-soluble azo dyes by utilizes continuous diazotization reaction and continuous coupling reaction in a pipeline reactor. The diazo component, hydrochloric acid and sodium nitrite are simultaneously fed at the bottom of the pipeline reactor at room temperature, to perform a diazotization reaction in the pipeline and leave the diazotization reaction site in time, followed by performing the coupling reaction with the introduced coupled component. Under stirring of micro stirring blades, the materials at each flow layer are uniformly mixed and reacted, and the reaction materials flow upward under the action of a feed driving force and are discharged from the top of the continuous reactor to produce a water-soluble azo dye.

A method for producing water-soluble azo dyes by utilizes continuous diazotization reaction and continuous coupling reaction in a pipeline reactor. The diazo component, hydrochloric acid and sodium nitrite are simultaneously fed at the bottom of the pipeline reactor at room temperature, to perform a diazotization reaction in the pipeline and leave the diazotization reaction site in time, followed by performing the coupling reaction with the introduced coupled component. Under stirring of micro stirring blades, the materials at each flow layer are uniformly mixed and reacted, and the reaction materials flow upward under the action of a feed driving force and are discharged from the top of the continuous reactor to produce a water-soluble azo dye.

Compositions, devices, systems and methods for increasing the signal to noise ratio (SNR) and/or enhancing photoprotection in an illuminated analytical reaction by addition of one or more signal detection assay (SDA)-enhancing agents to the reaction mixture.

Compositions, devices, systems and methods for increasing the signal to noise ratio (SNR) and/or enhancing photoprotection in an illuminated analytical reaction by addition of one or more signal detection assay (SDA)-enhancing agents to the reaction mixture.

Compositions, devices, systems and methods for increasing the signal to noise ratio (SNR) and/or enhancing photoprotection in an illuminated analytical reaction by addition of one or more signal detection assay (SDA)-enhancing agents to the reaction mixture.

Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition. ##STR00001##

Disclosed is a group of azo quencher compositions useful as fluorescence quenchers having the general structure of formula 1, methods of making or using the compositions, and kits comprising the composition. ##STR00001##