The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells. ##STR00001##

The present invention relates to: a labeling dye having excellent fluorescent intensity and photostability; and a kit.

An infrared-absorbing composition includes particles of an infrared-absorbing coloring agent and a solvent, in which the particles in the infrared-absorbing composition have two or more maximal absorption wavelengths exhibited in a wavelength range of 650 to 1500 nm, and in the range, in a case where an absorbance at a maximal absorption wavelength existing on a second shortest wavelength side is set to 1, an absorbance at a maximal absorption wavelength existing on a shortest wavelength side is 0.6 to 2.0.

An infrared-absorbing composition includes particles of an infrared-absorbing coloring agent and a solvent, in which the particles in the infrared-absorbing composition have two or more maximal absorption wavelengths exhibited in a wavelength range of 650 to 1500 nm, and in the range, in a case where an absorbance at a maximal absorption wavelength existing on a second shortest wavelength side is set to 1, an absorbance at a maximal absorption wavelength existing on a shortest wavelength side is 0.6 to 2.0.

A series of 8-(bisphenylethynyl)-ester flexible multiple ring-containing fluoroboron pyrrole liquid crystal dyes are synthesized by introducing a diphenylethynyl rigid structure at position 8 of a boron-dipyrromethene core via a Sonogashira coupling reaction, and a flexible multiple ring such as bicyclohexane, or cholesterol is connected to the biphenylethynyl via an esterification reaction. The dye compounds all have maximum emission wavelengths in methylene chloride concentrated around 525 nm, present green fluorescence, and show good dichroic colour ratios and ordered parameters in E7 liquid crystal. The liquid crystal compounds are in a liquid crystal intermediate phase within the range of 100-280° C., and may be used for manufacturing liquid crystal display products, especially as guest dyes for guest-host mode liquid crystal displays. The response time can be improved and a rapid response effect achieved when the compounds are added to E7 liquid crystal and used for a guest-host display mode.

A method for determining a glomerular filtration rate (GFR) in a patient includes administering to said patient a compound of Formula I and transdermally measuring spectral energy emitted by the compound of Formula I over a measurement time window. The spectral energy is emitted by the compound of Formula I in response to electromagnetic radiation delivered to the compound of Formula I. The method also includes determining the GFR in said patient based on the measured spectral energy emitted by the compound of Formula I over the measurement time window by fitting an exponential function to the spectral energy as a function of time or a linear function to the log of the spectral energy as a function of time to calculate a rate constant associated with renal clearance over the measurement time window and directly related to the GFR normalized to a body size metric of the patient.

A method for determining a glomerular filtration rate (GFR) in a patient includes administering to said patient a compound of Formula I and transdermally measuring spectral energy emitted by the compound of Formula I over a measurement time window. The spectral energy is emitted by the compound of Formula I in response to electromagnetic radiation delivered to the compound of Formula I. The method also includes determining the GFR in said patient based on the measured spectral energy emitted by the compound of Formula I over the measurement time window by fitting an exponential function to the spectral energy as a function of time or a linear function to the log of the spectral energy as a function of time to calculate a rate constant associated with renal clearance over the measurement time window and directly related to the GFR normalized to a body size metric of the patient.

The invention relates to novel, water-soluble fluorescent dyes with high fluorescence quantum yield based on oxygen-containing heterocycles, their reactive derivatives and dye conjugates, and their use for labelling samples and detecting analytes. The compounds of the new dye class are compatible with commercial excitation light sources and are characterised by Stokes shifts of more than 50 nm.

The invention relates to novel, water-soluble fluorescent dyes with high fluorescence quantum yield based on oxygen-containing heterocycles, their reactive derivatives and dye conjugates, and their use for labelling samples and detecting analytes. The compounds of the new dye class are compatible with commercial excitation light sources and are characterised by Stokes shifts of more than 50 nm.

Provided are a resin composition including a pigment, a compound A which includes 3 or more basic groups in one molecule, has an amine value of 2.7 mmol/g or more, and has a molecular weight of 100 or more, and a resin having an acid group, in which the pigment is included in an amount of 40% by mass or more in a total solid content of the resin composition; a film formed of the resin composition; and an optical filter, a solid-state imaging element, and an image display device, which include the film.