Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.

Embodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.

The present invention relates to novel 3-oxindole derivatives, to a process for their preparation and to the use of said derivatives as dyes for manufacturing pH sensitive textiles and as indicators in titration methods. The invention also relates to a method to manufacture pH sensitive textiles and to textiles so obtained.

Provided herein are compounds (i.e., fluorogenic amino acids (FgAAs), e.g., compounds of Formulae (I), (II), (III), and (IV)) that can be used in fluorescent labeling of biomolecules (e.g., proteins) and/or cells. Also described herein are methods of labeling and detecting biomolecules and/or cells by incorporating the FgAA compounds described herein into the biomolecules and/or cells (e.g., by enzymatic incorporation). Also provided herein are biomolecules, cells, compositions, and kits comprising the FgAA compounds described herein.

Provided herein are compounds (i.e., fluorogenic amino acids (FgAAs), e.g., compounds of Formulae (I), (II), (III), and (IV)) that can be used in fluorescent labeling of biomolecules (e.g., proteins) and/or cells. Also described herein are methods of labeling and detecting biomolecules and/or cells by incorporating the FgAA compounds described herein into the biomolecules and/or cells (e.g., by enzymatic incorporation). Also provided herein are biomolecules, cells, compositions, and kits comprising the FgAA compounds described herein.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and/or hosts of formula ##STR00001##
which have a sufficiently small energy gap between S.sub.1 and T.sub.1 (ΔE.sub.ST) to enable up-conversion of the triplet exciton from T.sub.1 to S.sub.1. The organic light emitting elements show high electroluminescent efficiency.

The present invention relates to organic light emitting elements, comprising thermally activated delayed fluorescence (TADF) emitters and/or hosts of formula ##STR00001##
which have a sufficiently small energy gap between S.sub.1 and T.sub.1 (ΔE.sub.ST) to enable up-conversion of the triplet exciton from T.sub.1 to S.sub.1. The organic light emitting elements show high electroluminescent efficiency.

Disclosed are a quinazolinone derivative, a preparation method therefor, a pharmaceutical composition, and applications. Provided are a compound represented by formula I, a pharmaceutically acceptable salt, a solvate, a crystal form, a eutectic crystal, a stereoisomer, an isotope compound, a metabolite, or a prodrug thereof. Generation or activity of a cell factor can be regulated, and accordingly, cancers and inflammatory diseases can be effectively treated. ##STR00001##

A display device including a laminate includes a wavelength selective absorption layer containing a resin, a dye including at least one of four specific dyes A to D, and an antifading agent for a dye, and includes a gas barrier layer, and a wavelength conversion material; the laminate includes a wavelength selective absorption layer containing a resin, a dye, and an electron migration-type antifading agent in which the energy level of the highest occupied molecular orbital and the lowest unoccupied molecular orbital satisfy a specific relational expression in relation to the dye, and includes the gas barrier layer; an organic electroluminescent display device includes this laminate. The gas barrier layer contains a crystalline resin, has a layer thickness of 0.1 μm to 10 μm, has a layer oxygen permeability of 60 cc/m.sup.2.Math.day.Math.atm or less, and is directly arranged on at least one surface of the wavelength selective absorption layer.

A display device including a laminate includes a wavelength selective absorption layer containing a resin, a dye including at least one of four specific dyes A to D, and an antifading agent for a dye, and includes a gas barrier layer, and a wavelength conversion material; the laminate includes a wavelength selective absorption layer containing a resin, a dye, and an electron migration-type antifading agent in which the energy level of the highest occupied molecular orbital and the lowest unoccupied molecular orbital satisfy a specific relational expression in relation to the dye, and includes the gas barrier layer; an organic electroluminescent display device includes this laminate. The gas barrier layer contains a crystalline resin, has a layer thickness of 0.1 μm to 10 μm, has a layer oxygen permeability of 60 cc/m.sup.2.Math.day.Math.atm or less, and is directly arranged on at least one surface of the wavelength selective absorption layer.